INTRABUCCALLY DISINTEGRATING PREPARATION AND PRODUCTION THEREOF

Title:

INTRABUCCALLY DISINTEGRATING PREPARATION AND PRODUCTION THEREOF

Document Type and Number:

WIPO Patent Application WO/1993/012769

Kind Code:

A1

Abstract:

A solid preparation soluble in the buccal cavity, which is composed of a sugar comprising lactose and/or manitol and 0.1-1.2 w/w%, based on the sugar, of agar and an active ingredient and has a density of 400-1,000 mg/ml and such a strength as to withstand the handling in the manufacture thereof. It has such a sufficient practical solubility in the buccal cavity that even the aged or children having difficulty in swallowing a solid preparation, such as a tablet, can take it. It has an exceedingly high strength as compared with conventional open matrix structures and hence can withstand satisfactorily carrying and PTP packaging.

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Inventors:

MASAKI KATSUHIRO (JP)
BAN KAZUTOSHI (JP)

Application Number:

PCT/JP1992/001631

Publication Date:

July 08, 1993

Filing Date:

December 15, 1992

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)

International Classes:

A61K9/00; A61K9/20; (IPC1-7): A61K9/20; A61K47/10; A61K47/26; A61K47/36

Foreign References:

JPH0386837A	1991-04-11
JPH0232014A	1990-02-01
JPS6479109A	1989-03-24
JPH0232014A	1990-02-01
JPS6250445B2	1987-10-24
JPH0356412A	1991-03-12

Other References: