INTRACELLULAR BINDING PROTEINS AND USE THEREOF

Title:

INTRACELLULAR BINDING PROTEINS AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO1994029446

Kind Code:

A3

Abstract:

PCT No. PCT/FR94/00714 Sec. 371 Date Dec. 28, 1995 Sec. 102(e) Date Dec. 28, 1995 PCT Filed Jun. 15, 1994 PCT Pub. No. WO94/29446 PCT Pub. Date Dec. 22, 1994The present invention relates to nucleic acid sequences encoding intracellular binding proteins. More particularly, the nucleic acid comprises a gene coding for an intracellular single chain antibody specific for a ras oncogene under the control of a promoter, the antibody is functional in mammalian cells, and inhibits the transformation of cells that express a ras oncogene.

Inventors:

SCHWEIGHOFFER FABIEN (FR)
TOCQUE BRUNO (FR)

Application Number:

PCT/FR1994/000714

Publication Date:

February 02, 1995

Filing Date:

June 15, 1994

Export Citation:

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Assignee:

RHONE POULENC RORER SA (FR)
SCHWEIGHOFFER FABIEN (FR)
TOCQUE BRUNO (FR)

International Classes:

A61K31/70; C12N15/09; A61K39/12; C07H21/04; C07K16/00; C07K16/08; C07K16/10; C07K16/18; C07K16/32; C12N7/00; C12N15/00; C12N15/12; C12N15/13; C12N15/86; C12P21/02; C12P21/08; A61K38/00; C12R1/91; (IPC1-7): C12N15/12; C12N15/13

Foreign References:

DE3915952A1

1990-12-06

Other References:

RODWELL, J.D.: "Engineering monoclonal antibodies", NATURE., vol. 342, 2 November 1989 (1989-11-02), LONDON GB, pages 99 - 100
RUSSELL, S.J. ET AL.;: "Retroviral vectors displaying functional antibody fragments.", NUCLEIC ACIDS RESEARCH., vol. 21, no. 5, 11 March 1993 (1993-03-11), ARLINGTON, VIRGINIA US, pages 1081 - 1085

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