Title:
INTRACELLULAR SIGNALING-INDUCED RET-INDEPENDENT GDNF RECEPTOR-EFFECTED MORPHOLOGICAL CHANGES
Document Type and Number:
WIPO Patent Application WO2004078775
Kind Code:
A3
Abstract:
The invention provides methods for identifying modulators of RETindependent, GDNF effected intracellular signaling. The invention further provides methods of identifying useful modulators of RET-independent GDNF receptoreffected MET activation, as well as modulators of morphological responses which are effected by nonRET GDNF receptor-effected intracellular signaling. Methods of distinguishing RET-independent GDNF ligand-mediated intracellular signaling by different cellular GDNF receptors from RET-dependent intracellular signaling are provided. The methods of the invention also provide an understanding of the complex interrelationships between RET, MET, GFRa in response to GDNF ligands.
Inventors:
SARIOLA HANNU (FI)
POPSUEVA ANNA (FI)
SAARMA MART (FI)
POPSUEVA ANNA (FI)
SAARMA MART (FI)
Application Number:
PCT/IB2004/000985
Publication Date:
April 28, 2005
Filing Date:
March 05, 2004
Export Citation:
Assignee:
LICENTIA LTD (FI)
SARIOLA HANNU (FI)
POPSUEVA ANNA (FI)
SAARMA MART (FI)
SARIOLA HANNU (FI)
POPSUEVA ANNA (FI)
SAARMA MART (FI)
International Classes:
C07K14/705; G01N33/50; G01N33/68; C07K; (IPC1-7): G01N33/68; C07K14/705
Domestic Patent References:
| WO2000020867A1 | 2000-04-13 |
Other References:
SARIOLA HANNU ET AL: "GDNF and its receptors in the regulation of the ureteric branching", INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 43, no. 5, 1999, pages 413 - 418, XP002302436, ISSN: 0214-6282
POTERYAEV D ET AL: "GDNF triggers a novel Ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 463, no. 1-2, 10 December 1999 (1999-12-10), pages 63 - 66, XP004260683, ISSN: 0014-5793
TRUPP M ET AL: "RET-DEPENDENT AND -INDEPENDENT MECHANISMS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR SIGNALING IN NEURONAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 30, 23 July 1999 (1999-07-23), pages 20885 - 20894, XP000889729, ISSN: 0021-9258
O'ROURKE D A ET AL: "EXPRESSION OF C-RET PROMOTES MORPHOGENESIS AND CELL SURVIVAL IN MIMCD-3 CELLS", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 45, no. 4, April 1999 (1999-04-01), pages 581 - 588, XP000885646, ISSN: 0002-9513
POPSUEVA ANNA ET AL: "GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase.", JOURNAL OF CELL BIOLOGY, vol. 161, no. 1, 14 April 2003 (2003-04-14), pages 119 - 129, XP002302437, ISSN: 0021-9525
POTERYAEV D ET AL: "GDNF triggers a novel Ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 463, no. 1-2, 10 December 1999 (1999-12-10), pages 63 - 66, XP004260683, ISSN: 0014-5793
TRUPP M ET AL: "RET-DEPENDENT AND -INDEPENDENT MECHANISMS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR SIGNALING IN NEURONAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 30, 23 July 1999 (1999-07-23), pages 20885 - 20894, XP000889729, ISSN: 0021-9258
O'ROURKE D A ET AL: "EXPRESSION OF C-RET PROMOTES MORPHOGENESIS AND CELL SURVIVAL IN MIMCD-3 CELLS", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 45, no. 4, April 1999 (1999-04-01), pages 581 - 588, XP000885646, ISSN: 0002-9513
POPSUEVA ANNA ET AL: "GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase.", JOURNAL OF CELL BIOLOGY, vol. 161, no. 1, 14 April 2003 (2003-04-14), pages 119 - 129, XP002302437, ISSN: 0021-9525
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