Title:
INTRAVASCULAR INDWELLING CATHETER LOCK SOLUTION CONTAINING ACETIC ACID AND CONTAINER CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2010/064324
Kind Code:
A1
Abstract:
A catheter lock solution which is a catheter lock preparation having a bacteriostatic property at physiological osmotic pressure without practically containing a bacteriostatic component such as a preservative, an antimicrobial agent, or an antibiotic and having high safety, characterized in that the preparation contains a weak acid having an acid dissociation constant (pKa) of 3.0 to 6.5 as a buffer, a pH of the solution is less than 6.0, preferably from 3.0 to about 5.5, an osmotic pressure ratio is from 0.5 to 3.0, and a pH change (variation) can be suppressed to less than the 6.0 with the weak acid; and a container containing the catheter lock solution.
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Inventors:
KIMURA YUKO (JP)
SUZUKI KOJI (JP)
IWATA MINORU (JP)
IWAMOTO SUMIKA (JP)
YAMAMOTO TAKASHI (JP)
SUZUKI KOJI (JP)
IWATA MINORU (JP)
IWAMOTO SUMIKA (JP)
YAMAMOTO TAKASHI (JP)
Application Number:
PCT/JP2008/072186
Publication Date:
June 10, 2010
Filing Date:
December 05, 2008
Export Citation:
Assignee:
JMS CO LTD (JP)
KIMURA YUKO (JP)
SUZUKI KOJI (JP)
IWATA MINORU (JP)
IWAMOTO SUMIKA (JP)
YAMAMOTO TAKASHI (JP)
KIMURA YUKO (JP)
SUZUKI KOJI (JP)
IWATA MINORU (JP)
IWAMOTO SUMIKA (JP)
YAMAMOTO TAKASHI (JP)
International Classes:
A61K33/42; A61K31/194; A61K31/727; A61L29/00; A61P7/02
Foreign References:
| JP2002523336A | 2002-07-30 | |||
| JP2003183154A | 2003-07-03 | |||
| JP2006232829A | 2006-09-07 | |||
| JP2005517460A | 2005-06-16 | |||
| JP2008100926A | 2008-05-01 | |||
| JP2003183154A | 2003-07-03 | |||
| JP2002523336A | 2002-07-30 |
Other References:
"Guidelines for the Prevention of Intravascular Catheter-Related infections", 9 August 2002, UNTIED STATES, MORBIDITY AND MORTALITY WEEKLY REPORT
"Thoroughgoing Preventive Measure against Nosocomial Infection with Serratia", 19 July 2002, MINISTRY OF HEALTH, LABOR AND WELFARE, PHARMACEUTICAL AND FOOD SAFETY BUREAU, SAFETY DIVISION INFORMATION
DRUG INTELL CLIN PHARM, vol. 9, 1975, pages 154
J CLIN ONCOL, vol. 18, 2000, pages 1269 - 78
CARRATALA J, NIUBO J, FERNANDEZ-SEVILLA A ET AL.: "Randomized, doubleblind trial of an antibiotic-lock technique for prevention of grampositive central venous catheter-related infection in neutropenic patients with cancer", ANTIMICROB AGENTS CHEMOTHER, vol. 43, 1999, pages 2200 - 4
J CLIN ONCOL, vol. 8, 1990, pages 1591 - 7
CLIN INFECT DIS, vol. 25, 1997, pages 149 - 51
"Japanese Pharmacopoeia"
See also references of EP 2366397A4
"Thoroughgoing Preventive Measure against Nosocomial Infection with Serratia", 19 July 2002, MINISTRY OF HEALTH, LABOR AND WELFARE, PHARMACEUTICAL AND FOOD SAFETY BUREAU, SAFETY DIVISION INFORMATION
DRUG INTELL CLIN PHARM, vol. 9, 1975, pages 154
J CLIN ONCOL, vol. 18, 2000, pages 1269 - 78
CARRATALA J, NIUBO J, FERNANDEZ-SEVILLA A ET AL.: "Randomized, doubleblind trial of an antibiotic-lock technique for prevention of grampositive central venous catheter-related infection in neutropenic patients with cancer", ANTIMICROB AGENTS CHEMOTHER, vol. 43, 1999, pages 2200 - 4
J CLIN ONCOL, vol. 8, 1990, pages 1591 - 7
CLIN INFECT DIS, vol. 25, 1997, pages 149 - 51
"Japanese Pharmacopoeia"
See also references of EP 2366397A4
Attorney, Agent or Firm:
KAWASHIMA, TOSHIKAZU (JP)
Toshikazu Kawashima (JP)
Toshikazu Kawashima (JP)
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