Title:
IRAK DEGRADERS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/127283
Kind Code:
A3
Abstract:
The present invention provides compounds, compositions thereof, and methods of using the same.
Inventors:
WEISS MATTHEW M (US)
ZHENG XIAOZHANG (US)
ZHU XIAO (US)
ZHENG XIAOZHANG (US)
ZHU XIAO (US)
Application Number:
PCT/US2020/065757
Publication Date:
July 29, 2021
Filing Date:
December 17, 2020
Export Citation:
Assignee:
KYMERA THERAPEUTICS INC (US)
International Classes:
A61K47/64; A61K39/395; A61K47/68
Foreign References:
| US20190192668A1 | 2019-06-27 |
Other References:
EL-GAMAL ET AL.: "Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1 R) Kinase and Its Inhibitors", J. MED. CHEM., vol. 61, 2018, pages 5450 - 5466, XP055837830, DOI: 10.1021/acs.jmedchem.7b00873
NUNES JOAO, MCGONAGLE GRANT A., EDEN JESSICA, KIRITHARAN GIRIESHANIE, TOUZET MEGANE, LEWELL XIAO, EMERY JOHN, EIDAM HILARY, HARLIN: "Targeting IRAK4 for Degradation with PROTACs", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 7, 14 June 2019 (2019-06-14), US, pages 1081 - 1085, XP055785428, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00219
NUNES JOAO, MCGONAGLE GRANT A., EDEN JESSICA, KIRITHARAN GIRIESHANIE, TOUZET MEGANE, LEWELL XIAO, EMERY JOHN, EIDAM HILARY, HARLIN: "Targeting IRAK4 for Degradation with PROTACs", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 7, 14 June 2019 (2019-06-14), US, pages 1081 - 1085, XP055785428, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00219
Attorney, Agent or Firm:
REID, Andrea L.C. et al. (US)
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