Title:
IRTA-2 ANTIBODIES AND THEIR USES
Document Type and Number:
WIPO Patent Application WO2006076691
Kind Code:
A8
Abstract:
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
Inventors:
GRAZIANO ROBERT (US)
KING DAVID J (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE (US)
HUANG HAICHUN (US)
KING DAVID J (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE (US)
HUANG HAICHUN (US)
Application Number:
PCT/US2006/001444
Publication Date:
May 08, 2008
Filing Date:
January 12, 2006
Export Citation:
Assignee:
MEDAREX INC (US)
GRAZIANO ROBERT (US)
KING DAVID J (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE (US)
HUANG HAICHUN (US)
GRAZIANO ROBERT (US)
KING DAVID J (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE (US)
HUANG HAICHUN (US)
International Classes:
C07K16/00; A61K39/395; C07H21/04; C12Q1/68; C07K17/00
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