Title:
ISLET CELL SHEET, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/016423
Kind Code:
A1
Abstract:
Sheet-like islet cells can be produced by: culturing islet cells on a cell culture support, of which the surface has been coated with a polymer having a hydration force that changes in a temperature range from 0 to 80°C, at a temperature at which the hydration force of the polymer becomes weak; and subsequently changing the temperature of a culture solution to a temperature at which the hydration force of the polymer becomes strong. The sheet-like islet cells thus produced have an insulin production function even under blood-unflowing conditions.
Inventors:
SHIMIZU HIROFUMI (JP)
OHASHI KAZUO (JP)
UTOH RIE (JP)
ISE KAZUYA (JP)
YAMATO MASAYUKI (JP)
OKANO TERUO (JP)
GOTOH MITSUKAZU (JP)
OHASHI KAZUO (JP)
UTOH RIE (JP)
ISE KAZUYA (JP)
YAMATO MASAYUKI (JP)
OKANO TERUO (JP)
GOTOH MITSUKAZU (JP)
Application Number:
PCT/JP2010/063033
Publication Date:
February 10, 2011
Filing Date:
August 02, 2010
Export Citation:
Assignee:
UNIV TOKYO WOMENS MEDICAL (JP)
SHIMIZU HIROFUMI (JP)
OHASHI KAZUO (JP)
UTOH RIE (JP)
ISE KAZUYA (JP)
YAMATO MASAYUKI (JP)
OKANO TERUO (JP)
GOTOH MITSUKAZU (JP)
SHIMIZU HIROFUMI (JP)
OHASHI KAZUO (JP)
UTOH RIE (JP)
ISE KAZUYA (JP)
YAMATO MASAYUKI (JP)
OKANO TERUO (JP)
GOTOH MITSUKAZU (JP)
International Classes:
A61L27/00; C12N5/077
Domestic Patent References:
| WO2004091679A1 | 2004-10-28 | |||
| WO1997028252A1 | 1997-08-07 | |||
| WO2007080990A1 | 2007-07-19 |
Foreign References:
| JP2008278769A | 2008-11-20 | |||
| JP2006304791A | 2006-11-09 | |||
| JPH02211865A | 1990-08-23 | |||
| JPH05192138A | 1993-08-03 |
Other References:
LEE JEONGIK ET AL.: "A new method for manufacturing Immunoisolated Bio-artificial Pancreas with cell sheet engineering utilizing temperature-responsive culture dishes", TISS. CULT. RES. COMMUN., vol. 26, 2007, pages 115 - 123, XP008153607
MEIRIGENG QI ET AL.: "PVA hydrogel sheet macroencapsulation for the bioartificial pancreas", BIOMATERIALS, vol. 25, 2004, pages 5885 - 5892, XP004511127
HIROFUMI SHIMIZU ET AL.: "Ondo Otosei Baiyozara o Mochiita Kinoteki Suito Saibo Sheet no Kochiku", REGENERATIVE MEDICINE, vol. 8, 5 February 2009 (2009-02-05), pages 153, XP008155397
TATSUYA KIN ET AL.: "Survival and Metabolic Function of Syngeneic Rat Islet Grafts Transplanted in the Omental Pouch", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 3, 2003, pages 281 - 285, XP008152528
HIROFUMI SHIMIZU ET AL.: "Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus", BIOMATERIALS, vol. 30, October 2009 (2009-10-01), pages 5943 - 5949, XP026524659
TAKAHIRO SAITO ET AL.: "Suito Saibo ni yoru Tanso Saibo Sheet Sakusei to, Suito Soshiki Kogaku eno Tenkai", REGENERATIVE MEDICINE, vol. 9, 5 February 2010 (2010-02-05), pages 194, XP008155398
See also references of EP 2491957A4
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 355, 2006, pages 1318 - 1330
XENOTRANSPLANTATION, vol. 14, no. 4, 2007, pages 288 - 297
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 77, no. 5, 2005, pages 587 - 597
PHARMACOLOGICAL REVIEWS, vol. 58, 2006, pages 194 - 243
MEIRIGENG QI ET AL.: "PVA hydrogel sheet macroencapsulation for the bioartificial pancreas", BIOMATERIALS, vol. 25, 2004, pages 5885 - 5892, XP004511127
HIROFUMI SHIMIZU ET AL.: "Ondo Otosei Baiyozara o Mochiita Kinoteki Suito Saibo Sheet no Kochiku", REGENERATIVE MEDICINE, vol. 8, 5 February 2009 (2009-02-05), pages 153, XP008155397
TATSUYA KIN ET AL.: "Survival and Metabolic Function of Syngeneic Rat Islet Grafts Transplanted in the Omental Pouch", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 3, 2003, pages 281 - 285, XP008152528
HIROFUMI SHIMIZU ET AL.: "Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus", BIOMATERIALS, vol. 30, October 2009 (2009-10-01), pages 5943 - 5949, XP026524659
TAKAHIRO SAITO ET AL.: "Suito Saibo ni yoru Tanso Saibo Sheet Sakusei to, Suito Soshiki Kogaku eno Tenkai", REGENERATIVE MEDICINE, vol. 9, 5 February 2010 (2010-02-05), pages 194, XP008155398
See also references of EP 2491957A4
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 355, 2006, pages 1318 - 1330
XENOTRANSPLANTATION, vol. 14, no. 4, 2007, pages 288 - 297
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 77, no. 5, 2005, pages 587 - 597
PHARMACOLOGICAL REVIEWS, vol. 58, 2006, pages 194 - 243
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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