ISOCOUMARIN DERIVATIVES AND USE THEREOF IN DRUGS

Title:

ISOCOUMARIN DERIVATIVES AND USE THEREOF IN DRUGS

Document Type and Number:

WIPO Patent Application WO/1997/048693

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) and medicinal compositions thereof, wherein R represents hydrogen or C1-6 alkyl; and n is an integer of 0 or 1. These medicinal compositions are usable in the prevention or treatment of diseases accompanying immunonomodulatory abnormalities or neovascularization.

Inventors:

HIRANO SHIN-ICHI (JP)
MASE TOSHIYUKI (JP)
AGATA NAOKI (JP)
IGUCHI HIROSHI (JP)
MATSUMOTO NAOKI (JP)
YOSHIOKA TAKEO (JP)
TONE HIROSHI (JP)
KUMAGAI HIROYUKI (JP)
ISHIZUKA MASAAKI (JP)
TAKEUCHI TOMIO (JP)

Application Number:

PCT/JP1996/001657

Publication Date:

December 24, 1997

Filing Date:

June 17, 1996

Export Citation:

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Assignee:

MERCIAN CORP (JP)
HIRANO SHINICHI (JP)
MASE TOSHIYUKI (JP)
AGATA NAOKI (JP)
IGUCHI HIROSHI (JP)
MATSUMOTO NAOKI (JP)
YOSHIOKA TAKEO (JP)
TONE HIROSHI (JP)
KUMAGAI HIROYUKI (JP)
ISHIZUKA MASAAKI (JP)
TAKEUCHI TOMIO (JP)

International Classes:

A61K31/35; A61K31/352; A61K31/366; A61P1/04; A61P9/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P37/02; A61P37/06; C07D311/76; (IPC1-7): C07D311/76; A61K31/35

Foreign References:

JPH032177A	1991-01-08
JPH04112884A	1992-04-14
JPH0597841A	1993-04-20
JPH06183966A	1994-07-05

Other References:

YAMAZAKI M, MAEBAYASHI Y, MIYAKI K: "ISOLATION OF A NEW METABOLITE, 6-METHOXY-8-HYDROXYSOCOUMARIN-3-CARBOXYLIC ACID FROM ASPERGILLUS OCHRACEUS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 20, no. 10, 1 January 1972 (1972-01-01), JP, pages 2276 - 2278, XP002948932, ISSN: 0009-2363

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