ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF

WIPO Patent Application WO/2023/085785

A1

The present invention relates to an isoindolinone derivative compound having a glutarimide mother nucleus, and the application thereof and, more specifically, to an isoindolinone derivative compound having a glutarimide mother nucleus having a thalidomide analog. The compound of chemical formula 1 according to the present invention specifically binds to the CRBN protein and is involved in functions thereof. Thus, the compound of the present invention may be beneficially used in the prevention or treatment of leprosy, chronic graft versus host disease, inflammatory diseases, or cancer that are caused by actions of the CRBN protein.

HWANG JONG YEON (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
KIM PIL HO (KR)
PARK CHI HOON (KR)
KIM HYUN JIN (KR)
CHO YONG HEE (KR)
AKSHAY DIW (KR)

PCT/KR2022/017592

May 19, 2023

November 09, 2022

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KOREA RES INST CHEMICAL TECH (KR)

C07D401/14; A61K31/454; A61K31/506; A61P29/00; A61P35/00; A61P37/06; C07D401/04; C07D413/14; C07D417/14

WO2009085234A2	2009-07-09
WO2021198966A1	2021-10-07

KR20110019761A	2011-02-28
KR20170007531A	2017-01-18

HANSEN JOSHUA D., CORREA MATTHEW, ALEXANDER MATT, NAGY MARK, HUANG DEHUA, SAPIENZA JOHN, LU GANG, LEBRUN LAURIE A., CATHERS BRIAN : "CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 4, 25 February 2021 (2021-02-25), US , pages 1835 - 1843, XP093028582, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01489

GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)

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