Title:
ISOLATED ANTIGEN-BINDING PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061352
Kind Code:
A1
Abstract:
The present invention relates to an isolated antigen-binding protein, which comprises a CD3-binding moiety, wherein the CD3-binding moiety comprises amino acid sequences having at least 95% identity to heavy chain variable regions HCDR1, HCDR2 and HCDR3; the amino acid sequence of the HCDR1 is set forth in any one of SEQ ID NOs: 1 and 2; the amino acid sequence of the HCDR2 is set forth in any one of SEQ ID NOs: 3, 4 and 5; the amino acid sequence of the HCDR3 is set forth in SEQ ID NO: 6; and/or, the CD3-binding moiety comprises amino acid sequences having at least 95% identity to light chain variable regions LCDR1, LCDR2 and LCDR3; the amino acid sequence of the LCDR1 is set forth in any one of SEQ ID NOs: 7, 8 and 9; the amino acid sequence of the LCDR2 is set forth in any one of SEQ ID NOs: 11 and 12; the amino acid sequence of the LCDR3 is set forth in SEQ ID NO: 13, wherein the CD3-binding moiety can induce T cell activation.
Inventors:
SUN ZHE (CN)
LI DONGCHEN (CN)
LI DONGCHEN (CN)
Application Number:
PCT/CN2023/120746
Publication Date:
March 28, 2024
Filing Date:
September 22, 2023
Export Citation:
Assignee:
GUANGZHOU LINTONPHARM CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00
Domestic Patent References:
| WO2016081490A1 | 2016-05-26 | |||
| WO2022199555A1 | 2022-09-29 | |||
| WO2023072217A1 | 2023-05-04 |
Foreign References:
| CN107428835A | 2017-12-01 | |||
| CN104704004A | 2015-06-10 | |||
| CN107108748A | 2017-08-29 | |||
| CN104220461A | 2014-12-17 |
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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