Title:
ISOLATED HUMAN DRUG-METABOLIZING PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN DRUG-METABOLIZING PROTEINS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002034922
Kind Code:
A3
Abstract:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
Inventors:
MERKULOV GENNADY V
YAN CHUNHUA
DI FRANCESCO VALENTINA
BEASLEY ELLEN M
YAN CHUNHUA
DI FRANCESCO VALENTINA
BEASLEY ELLEN M
Application Number:
PCT/US2001/042528
Publication Date:
August 28, 2003
Filing Date:
October 05, 2001
Export Citation:
Assignee:
PE CORP NY (US)
International Classes:
A61K45/00; A61P43/00; C07K16/40; C12M1/00; C12N1/15; A01K67/027; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N9/02; C12N15/09; C12N15/53; C12Q1/02; C12Q1/25; C12Q1/68; G01N33/53; G01N33/566; G01N37/00; (IPC1-7): C12N15/53; C12N9/02; C07K16/40; C12Q1/68; G01N33/68
Domestic Patent References:
| WO1995030766A1 | 1995-11-16 | |||
| WO2001051638A2 | 2001-07-19 | |||
| WO2001040466A2 | 2001-06-07 | |||
| WO2001077137A1 | 2001-10-18 | |||
| WO2002016388A1 | 2002-02-28 |
Other References:
MATSUBARA S ET AL: "COMPLEMENTARY DNA CLONING AND INDUCIBLE EXPRESSION DURING PREGNANCY OF THE MESSENGER RNA FOR RABBIT PULMONARY PROSTAGLANDIN OMEGA HYDROXYLASE CYTOCHROME P-450-P-2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 27, 1987, pages 13366 - 13371, XP002241281, ISSN: 0021-9258
DATABASE EMBL [online] 15 March 1998 (1998-03-15), NCI-CGAP: "oh04f03.s1 NCI_CGAP_KID3 Homo sapiens cDNA clone IMAGE:1456829 3' similar to SW:CP48_RAT P24464 CYTOCHROME P450 IVA8; mRNA sequence.", XP002241282, retrieved from EBI, HINXTON, UK Database accession no. AA863360
DATABASE EMBL [online] 11 September 1997 (1997-09-11), NCI-CGAP: "nl81a02.s1 NCI_CGAP-Br2 Homo sapiens cDNA clone IMAGE:1057034 3' mRNA sequence", XP002241283, retrieved from EBI, HINXTON, UK Database accession no. AA557324
DATABASE GENESEQ [online] 17 December 2001 (2001-12-17), XP002241284, retrieved from EBI, HINXTON, UK Database accession no. AAS40801
DATABASE EMBL [online] 15 March 1998 (1998-03-15), NCI-CGAP: "oh04f03.s1 NCI_CGAP_KID3 Homo sapiens cDNA clone IMAGE:1456829 3' similar to SW:CP48_RAT P24464 CYTOCHROME P450 IVA8; mRNA sequence.", XP002241282, retrieved from EBI, HINXTON, UK Database accession no. AA863360
DATABASE EMBL [online] 11 September 1997 (1997-09-11), NCI-CGAP: "nl81a02.s1 NCI_CGAP-Br2 Homo sapiens cDNA clone IMAGE:1057034 3' mRNA sequence", XP002241283, retrieved from EBI, HINXTON, UK Database accession no. AA557324
DATABASE GENESEQ [online] 17 December 2001 (2001-12-17), XP002241284, retrieved from EBI, HINXTON, UK Database accession no. AAS40801
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