Title:
ISOLATED NUCLEIC ACID MOLECULES ENCODING A NOVEL PHOSPHOPROTEIN-DARPP-32, ENCODED PROTEIN AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2005113572
Kind Code:
A3
Abstract:
Provided herein are novel nucleic acid and amino acids sequences of a phosphoprotein derived from a Guinea pig. Methods and compositions for modulating the phosphorylation of the novel protein in a dopaminergic signaling pathway are also provided. Compounds identified by the disclosed methods may be used to treat disorders characterized by a aberrant or dysfunctional intracellular signaling pathway regulated by DARPP-32.
Inventors:
BRANDISH PHILIP E (US)
ACTON PAUL J (US)
WEI NAN (US)
ACTON PAUL J (US)
WEI NAN (US)
Application Number:
PCT/US2005/017356
Publication Date:
February 16, 2006
Filing Date:
May 17, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
BRANDISH PHILIP E (US)
ACTON PAUL J (US)
WEI NAN (US)
BRANDISH PHILIP E (US)
ACTON PAUL J (US)
WEI NAN (US)
International Classes:
C07H21/04; C07K14/705; (IPC1-7): C07K14/00; C07H21/04; C07K16/00; C12P21/06; G01N33/53
Other References:
KURIHARA T ET AL: "Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein.", J NEUROSCIENCE., vol. 8, no. 2, February 1988 (1988-02-01), pages 508 - 517, XP002993645
BIBB J.A. ET AL: "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.", NATURE., vol. 402, no. 6762, 9 December 1999 (1999-12-09), pages 669 - 671, XP000999338
See also references of EP 1756144A4
BIBB J.A. ET AL: "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.", NATURE., vol. 402, no. 6762, 9 December 1999 (1999-12-09), pages 669 - 671, XP000999338
See also references of EP 1756144A4
Download PDF:
Previous Patent: METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS
Next Patent: METHOD OF SUPPORT-BASED CHEMICAL SYNTHESIS
Next Patent: METHOD OF SUPPORT-BASED CHEMICAL SYNTHESIS