Title:
ISOLATED STROMAL CELLS FOR USE IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO1999043286
Kind Code:
A3
Abstract:
Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the central nervous system of the human patient, wherein the presence of the isolated stromal cells in the brain effects treatment of the disease, disorder or condition. Stomal cells which are isolated may be cultured in vitro, they may be genetically engineered to produce therapeutic compounds, and/or they may be pre-differentiated prior to administration into the central nervous system.
Inventors:
PROCKOP DARWIN J (US)
STOKES DAVID G (US)
AZIZI S AUSIM (US)
PHINNEY DONALD G (US)
STOKES DAVID G (US)
AZIZI S AUSIM (US)
PHINNEY DONALD G (US)
Application Number:
PCT/US1999/003897
Publication Date:
December 02, 1999
Filing Date:
February 24, 1999
Export Citation:
Assignee:
UNIV MCP HAHNEMANN (US)
PROCKOP DARWIN J (US)
STOKES DAVID G (US)
AZIZI S AUSIM (US)
PHINNEY DONALD G (US)
PROCKOP DARWIN J (US)
STOKES DAVID G (US)
AZIZI S AUSIM (US)
PHINNEY DONALD G (US)
International Classes:
C12N15/09; A61K35/28; A61K38/00; A61K38/17; A61K38/22; A61K38/44; A61K39/395; A61K48/00; A61P11/00; A61P25/00; A61P25/16; A61P35/00; A61P43/00; C07K14/47; C07K14/61; C07K14/745; C07K14/78; C12M3/06; C12N5/0775; C12N5/079; C12N5/10; A61K35/12; (IPC1-7): A61K35/00; C12N15/85; C12N15/86
Foreign References:
| US5082670A | 1992-01-21 |
Other References:
ROSENBERG M. B., ET AL.: "GRAFTING GENETICALLY MODIFIED CELLS TO THE DAMAGED BRAIN: RESTORATIVE EFFECTS OF NGF EXPRESSION.", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 242., 16 December 1988 (1988-12-16), US, pages 1575 - 1578., XP002922608, ISSN: 0036-8075, DOI: 10.1126/science.3201248
GAGE F. H., KAWAJA M. D., FISHER L. J.: "GENETICALLY MODIFIED CELLS: APPLICATIONS FOR INTRACEREBRAL GRAFTING", TRENDS IN NEUROSCIENCE., ELSEVIER, AMSTERDAM., NL, vol. 14., 1 January 1991 (1991-01-01), NL, XP002922609, ISSN: 0166-2236, DOI: 10.1016/0166-2236(91)90156-O
FREED W. J., ET AL.: "GENETICALLY ALTERED AND DEFINED CELL LINES FOR TRANSPLANTATION IN ANIMAL MODELS OF PARKINSON'S DISEASE.", PROGRESS IN BRAIN RESEARCH., ELSEVIER AMSTERDAM., NL, vol. 82., 1 January 1990 (1990-01-01), NL, pages 11 - 21., XP002922610, ISSN: 0079-6123
WOLFF J. A., ET AL.: "GRAFTING FIBROBLASTS GENETICALLY MODIFIED TO PRODUCE L-DOPA IN A RAT MODEL OF PARKINSON DISEASE.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 86., 1 November 1989 (1989-11-01), US, pages 9011 - 9014., XP002922611, ISSN: 0027-8424, DOI: 10.1073/pnas.86.22.9011
GAGE F. H., ET AL.: "GRAFTING GENETICALLY-MODIFIED CELLS TO THE BRAIN: POSSIBILITIES FOR THE FUTURE.", NEUROSCIENCE, NEW YORK, NY, US, vol. 23., no. 03., 1 January 1987 (1987-01-01), US, pages 795 - 807., XP002922612, ISSN: 0306-4522, DOI: 10.1016/0306-4522(87)90159-X
SLOAN D. J., WOOD M. J., CHARLTON H. M.: "THE IMMUNE RESPONSE TO INTRACEREBRAL NEURAL GRAFTS.", TRENDS IN NEUROSCIENCE., ELSEVIER, AMSTERDAM., NL, vol. 14., no. 08., 1 January 1991 (1991-01-01), NL, pages 341 - 346., XP002922613, ISSN: 0166-2236, DOI: 10.1016/0166-2236(91)90159-R
AZIZI S. A., ET AL.: "ENGRAFTMENT AND MIGRATION OF HUMAN BONE MARROW STROMAL CELLS IMPLANTED IN THE BRAINS OF ALBINO RATS-SIMILARITIES TO ASTROCYTE GRAFTS.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 95., 1 March 1998 (1998-03-01), US, pages 3908 - 3913., XP002922614, ISSN: 0027-8424, DOI: 10.1073/pnas.95.7.3908
GAGE F. H., KAWAJA M. D., FISHER L. J.: "GENETICALLY MODIFIED CELLS: APPLICATIONS FOR INTRACEREBRAL GRAFTING", TRENDS IN NEUROSCIENCE., ELSEVIER, AMSTERDAM., NL, vol. 14., 1 January 1991 (1991-01-01), NL, XP002922609, ISSN: 0166-2236, DOI: 10.1016/0166-2236(91)90156-O
FREED W. J., ET AL.: "GENETICALLY ALTERED AND DEFINED CELL LINES FOR TRANSPLANTATION IN ANIMAL MODELS OF PARKINSON'S DISEASE.", PROGRESS IN BRAIN RESEARCH., ELSEVIER AMSTERDAM., NL, vol. 82., 1 January 1990 (1990-01-01), NL, pages 11 - 21., XP002922610, ISSN: 0079-6123
WOLFF J. A., ET AL.: "GRAFTING FIBROBLASTS GENETICALLY MODIFIED TO PRODUCE L-DOPA IN A RAT MODEL OF PARKINSON DISEASE.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 86., 1 November 1989 (1989-11-01), US, pages 9011 - 9014., XP002922611, ISSN: 0027-8424, DOI: 10.1073/pnas.86.22.9011
GAGE F. H., ET AL.: "GRAFTING GENETICALLY-MODIFIED CELLS TO THE BRAIN: POSSIBILITIES FOR THE FUTURE.", NEUROSCIENCE, NEW YORK, NY, US, vol. 23., no. 03., 1 January 1987 (1987-01-01), US, pages 795 - 807., XP002922612, ISSN: 0306-4522, DOI: 10.1016/0306-4522(87)90159-X
SLOAN D. J., WOOD M. J., CHARLTON H. M.: "THE IMMUNE RESPONSE TO INTRACEREBRAL NEURAL GRAFTS.", TRENDS IN NEUROSCIENCE., ELSEVIER, AMSTERDAM., NL, vol. 14., no. 08., 1 January 1991 (1991-01-01), NL, pages 341 - 346., XP002922613, ISSN: 0166-2236, DOI: 10.1016/0166-2236(91)90159-R
AZIZI S. A., ET AL.: "ENGRAFTMENT AND MIGRATION OF HUMAN BONE MARROW STROMAL CELLS IMPLANTED IN THE BRAINS OF ALBINO RATS-SIMILARITIES TO ASTROCYTE GRAFTS.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 95., 1 March 1998 (1998-03-01), US, pages 3908 - 3913., XP002922614, ISSN: 0027-8424, DOI: 10.1073/pnas.95.7.3908
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