Title:
ISOQUINOLINONE DERIVATIVES SERVING AS ROCK PROTEIN KINASE INHIBITORS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/253882
Kind Code:
A1
Abstract:
Disclosed are a series of isoquinolinone derivatives as ROCK protein kinase inhibitors and use thereof in preparing medicaments for ROCK protein kinase inhibitor-related glaucoma or ocular hypertension diseases. Specifically, disclosed are a compound of formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
Inventors:
LIU YIZHI (CN)
WANG YANDONG (CN)
WU LINGYUN (CN)
YOU XU (CN)
XIAO ZHEMING (CN)
CHEN SHUHUI (CN)
WANG YANDONG (CN)
WU LINGYUN (CN)
YOU XU (CN)
XIAO ZHEMING (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2020/097503
Publication Date:
December 24, 2020
Filing Date:
June 22, 2020
Export Citation:
Assignee:
ZHONGSHAN OPHTHALMIC CT SUN YAT SEN UNIV (CN)
International Classes:
C07D401/12; A61K31/551; A61P7/02; A61P9/08; A61P9/10; A61P9/12; A61P27/06; C07D401/14
Domestic Patent References:
| WO2004106325A1 | 2004-12-09 | |||
| WO2006057397A1 | 2006-06-01 | |||
| WO2007026664A1 | 2007-03-08 |
Foreign References:
| CN101622243A | 2010-01-06 | |||
| CN105085478A | 2015-11-25 | |||
| CN101253166A | 2008-08-27 | |||
| CN105085525A | 2015-11-25 | |||
| CN201910544202A | 2019-06-21 | |||
| CN201911078066A | 2019-11-06 |
Other References:
See also references of EP 3988544A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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