Title:
ISOQUINUCLIDINE DERIVATIVE AND METHOD FOR PRODUCING 1-CYCLOHEXENE-1-CARBOXYLIC ACID DERIVATIVE BY USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2008/013269
Kind Code:
A1
Abstract:
Disclosed is an isoquinuclidine derivative which enables to easily synthesize
oseltamivir or an analogue thereof. Specifically disclosed is an isoquinuclidine
derivative represented by the formula (1) below or a mirror image structure of
the formula (1). (1) (In the formula (1), A represents a protective
group of a nitrogen atom; R1-R6 independently represent
an optionally substituted alkyl group, an optionally substituted aryl group
or a hydrogen atom; and X represents a halogen.)
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Inventors:
FUKUYAMA TOHRU (JP)
YOKOSHIMA SATOSHI (JP)
SATOH NOBUHIRO (JP)
YOKOSHIMA SATOSHI (JP)
SATOH NOBUHIRO (JP)
Application Number:
PCT/JP2007/064780
Publication Date:
January 31, 2008
Filing Date:
July 27, 2007
Export Citation:
Assignee:
UNIV TOKYO (JP)
FUKUYAMA TOHRU (JP)
YOKOSHIMA SATOSHI (JP)
SATOH NOBUHIRO (JP)
FUKUYAMA TOHRU (JP)
YOKOSHIMA SATOSHI (JP)
SATOH NOBUHIRO (JP)
International Classes:
C07D491/18; C07C269/00; C07C269/06; C07C271/24; C07D453/06
Domestic Patent References:
| WO1998007685A1 | 1998-02-26 | |||
| WO1998007685A1 | 1998-02-26 |
Foreign References:
| JP2001354635A | 2001-12-25 |
Other References:
TOMISAWA H. ET AL.: "Studies on 1-Alkyl-2(1H)-pyridone Derivatives. XXVII. The Diels-Alder Reactions of 1-Methyl-2(1H)-pyridone with Methyl Acrylate and Acrylonitrile", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 27, no. 3, 1979, pages 670 - 675, XP000617377
KARPF M. ET AL.: "New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu)", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 6, 2001, pages 2044 - 2051, XP002286595
J. AM. CHEM. SOC., vol. 128, 2006, pages 6310 - 6311
J. AM. CHEM. SOC., vol. 128, 2006, pages 6312 - 6313
KARPF M. ET AL.: "New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu)", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 6, 2001, pages 2044 - 2051, XP002286595
J. AM. CHEM. SOC., vol. 128, 2006, pages 6310 - 6311
J. AM. CHEM. SOC., vol. 128, 2006, pages 6312 - 6313
Attorney, Agent or Firm:
ITEC INTERNATIONAL PATENT FIRM (3-3 Uchisaiwai-cho 1-chome, Chiyoda-k, Tokyo 11, JP)
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