ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

Title:

ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

Document Type and Number:

WIPO Patent Application WO/2005/054213

Kind Code:

A1

Abstract:

Compounds represented by the formula (I):[wherein R¹ to R¹⁰ each independently is hydrogen, halogeno, optionally substituted lower alkyl, etc.; X¹ is -O-, -S-, -NR¹¹- (wherein R¹¹ is hydrogen, lower alkyl, etc.), -CR¹²R¹³CO-, -(CR¹²R¹³)_mO-, or -O(CR¹²R¹³)_m- (wherein R¹² and R¹³ each independently is hydrogen or lower alkyl and m is an integer of 1 to 3), etc.; X² is a single bond, -O-, -S-, -NR¹⁴- (wherein R¹⁴ is hydrogen, lower alkyl, etc., provided that R¹⁴ may be bonded to R⁶ to form a ring in cooperation with the adjacent atoms), or -CR¹⁵R¹⁶- (wherein R¹⁵ and R¹⁶ each independently is hydrogen or lower alkyl, provided that R¹⁵ may be bonded to R⁶ or R¹⁰ to form a ring in cooperation with the adjacent carbon atoms and R¹⁶ and R⁹ in combination may form a bond); and X³ is COOR¹⁷, C(=NR¹⁷)NR¹⁸OR¹⁹, etc.], pharmaceutically acceptable salts of the compounds, or solvates of any of these.

Inventors:

FUKUI YOSHIKAZU (JP)
SASATANI TAKASHI (JP)
MATSUMURA KEN-ICHI (JP)
ISHIZUKA NATSUKI (JP)
YANO TOSHISADA (JP)
KANDA YASUHIKO (JP)
CHOMEI NOBUO (JP)

Application Number:

PCT/JP2004/017706

Publication Date:

June 16, 2005

Filing Date:

November 29, 2004

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
FUKUI YOSHIKAZU (JP)
SASATANI TAKASHI (JP)
MATSUMURA KEN-ICHI (JP)
ISHIZUKA NATSUKI (JP)
YANO TOSHISADA (JP)
KANDA YASUHIKO (JP)
CHOMEI NOBUO (JP)

International Classes:

A61K31/42; A61K31/423; A61K31/4245; A61K31/427; A61K31/428; A61K31/435; A61K31/4427; A61K31/501; A61K31/502; A61K31/506; A61K31/536; A61K31/5377; A61K31/5395; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P15/00; A61P17/04; A61P17/06; A61P19/02; A61P19/10; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D261/08; C07D261/18; C07D261/20; C07D413/04; C07D413/06; C07D413/12; C07D417/12; (IPC1-7): C07D261/08; A61K31/42; A61K31/423; A61K31/4245; A61K31/427; A61K31/428; A61K31/435; A61K31/4427; A61K31/501; A61K31/502; A61K31/506; A61K31/536; A61K31/5377; A61K31/5395; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P15/00; A61P17/04; A61P17/06; A61P19/02; A61P19/10; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D261/18; C07D261/20; C07D413/04; C07D417/12

Domestic Patent References:

WO1999011255A1	1999-03-11
WO2001036365A2	2001-05-25
WO2002092550A1	2002-11-21

Foreign References:

US20040209936A1

2004-10-21

Other References: