Title:
JAK KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/023207
Kind Code:
A1
Abstract:
Disclosed are a JAK kinase inhibitor and use thereof. The JAK kinase inhibitor is a compound represented by formula (I) or a stereoisomer and a tautomer thereof or a pharmaceutically acceptable salt thereof or a solvate or prodrug thereof. The present invention further provides the use of the compound of formula I of the present invention in the preparation of drugs for preventing and/or treating JAK kinase-related diseases, especially in the preparation of drugs for preventing and/or treating diseases involving cartilage degradation and bone and/or joint degradation, conditions involving inflammation or immune response, endotoxin-driven disease states, cancer, and organ transplantation rejection.
Inventors:
QIN YINLIN (CN)
SU MEI (CN)
SU MEI (CN)
Application Number:
PCT/CN2020/107028
Publication Date:
February 11, 2021
Filing Date:
August 05, 2020
Export Citation:
Assignee:
JIANGSU CAREPHAR PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/4545; A61K31/54; A61P11/00; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P35/00; A61P35/02; A61P37/06; A61P37/08
Domestic Patent References:
| WO2009047514A1 | 2009-04-16 | |||
| WO2010010188A1 | 2010-01-28 | |||
| WO2017133423A1 | 2017-08-10 | |||
| WO2016179207A1 | 2016-11-10 |
Foreign References:
| CN102105471A | 2011-06-22 | |||
| CN102105471A | 2011-06-22 | |||
| CN102131390A | 2011-07-20 | |||
| CN102203093A | 2011-09-28 | |||
| CN101878212A | 2010-11-03 | |||
| CN107759587A | 2018-03-06 | |||
| CN107759587A | 2018-03-06 | |||
| CN101535307A | 2009-09-16 | |||
| CN108341814A | 2018-07-31 |
Other References:
CHRISTEL J. MENET ET AL.: "Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identiļ¬cation to GLPG0634", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 22, 4 November 2014 (2014-11-04), XP055272599, ISSN: 0022-2623, DOI: 20201006132610X
MICHAEL SIU ET AL.: "2-Amino-[1, 2, 4]triazolo[1, 5-a]pyridines as JAK2 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 15 June 2013 (2013-06-15), XP028690058, ISSN: 0960-894X, DOI: 20201006133009X
MICHAEL SIU ET AL.: "2-Amino-[1, 2, 4]triazolo[1, 5-a]pyridines as JAK2 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 17, 15 June 2013 (2013-06-15), XP028690058, ISSN: 0960-894X, DOI: 20201006133009X
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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