Title:
KAURANE TETRACYCLIC DITERPENOID DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/001115
Kind Code:
A1
Abstract:
Disclosed are a kaurane tetracyclic diterpenoid derivative, a preparation method therefor and a medical use thereof. The present invention specifically relates to a novel derivative of a kaurane tetracyclic diterpenoid compound shown in general formula (I) or general formula (II), or a stereoisomer, solvate, prodrug, metabolite, and pharmaceutically acceptable salt or eutectic crystal, and pharmaceutical composition thereof, as well as a preparation method and a use thereof in the preparation of a drug for inhibiting NLRP3 inflammasome.
Inventors:
XU JINYI (CN)
YAO HONG (CN)
XU SHENGTAO (CN)
LIU JUNKAI (CN)
WU HONGYU (CN)
HE CHEN (CN)
SHAO XIAO (CN)
XUE SONGTAO (CN)
LI JUNDA (CN)
NI XIANG (CN)
YAO HONG (CN)
XU SHENGTAO (CN)
LIU JUNKAI (CN)
WU HONGYU (CN)
HE CHEN (CN)
SHAO XIAO (CN)
XUE SONGTAO (CN)
LI JUNDA (CN)
NI XIANG (CN)
Application Number:
PCT/CN2022/141790
Publication Date:
January 04, 2024
Filing Date:
December 26, 2022
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D311/00; A61K31/352; A61K31/381; A61K31/395; A61P17/00; A61P19/02; A61P29/00; A61P37/00; C07D405/12; C07D409/12
Domestic Patent References:
| WO2021185912A1 | 2021-09-23 |
Foreign References:
| CN110151749A | 2019-08-23 | |||
| CN105473566A | 2016-04-06 | |||
| CN102321096A | 2012-01-18 | |||
| CN114874172A | 2022-08-09 |
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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