KERATIN-BINDING POLYPEPTIDES

Title:

KERATIN-BINDING POLYPEPTIDES

Document Type and Number:

WIPO Patent Application WO2005115306

Kind Code:

A3

Abstract:

The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

Inventors:

BARG HEIKO (DE)
SUBKOWSKI THOMAS (DE)
LEMAIRE HANS-GEORG (DE)
BOLLSCHWEILER CLAUS (DE)
PTOCK ARNE (DE)

Application Number:

PCT/EP2005/005599

Publication Date:

March 16, 2006

Filing Date:

May 24, 2005

Export Citation:

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Assignee:

BASF AG (DE)
BARG HEIKO (DE)
SUBKOWSKI THOMAS (DE)
LEMAIRE HANS-GEORG (DE)
BOLLSCHWEILER CLAUS (DE)
PTOCK ARNE (DE)

International Classes:

A61K8/64; A61Q3/00; A61Q5/12; A61Q19/00; C07K14/47; A61Q1/02; A61Q5/02; A61Q5/06; A61Q17/04; A61Q19/04; A61Q19/10; (IPC1-7): A61K7/48; A61K7/06; A61K7/04

Domestic Patent References:

WO2000055320A1

2000-09-21

Foreign References:

US20050170366A1

2005-08-04

Other References:

CHEONG J E LAI ET AL: "Molecular abnormalities of the desmosomal protein desmoplakin in human disease.", CLINICAL AND EXPERIMENTAL DERMATOLOGY. MAY 2005, vol. 30, no. 3, May 2005 (2005-05-01), pages 261 - 266, XP002355355, ISSN: 0307-6938

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