Title:
KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
Document Type and Number:
WIPO Patent Application WO2002030860
Kind Code:
A9
Abstract:
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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Inventors:
DASSEUX JEAN-LOUIS H
ONICIU CARMEN DANIELA
ONICIU CARMEN DANIELA
Application Number:
PCT/US2001/031872
Publication Date:
February 20, 2003
Filing Date:
October 11, 2001
Export Citation:
Assignee:
ESPERION THERAPEUTICS INC (US)
International Classes:
A23K1/16; A61K31/10; A61K31/121; A61K31/16; A61K31/194; A61K31/20; A61K31/225; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/08; A61P7/02; A61P9/00; A61P9/12; A61P13/12; A61P15/10; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07C49/17; C07C49/185; C07C49/215; C07C49/245; C07C49/258; C07C49/507; C07C49/723; C07C49/743; C07C49/747; C07C49/782; C07C49/82; C07C49/83; C07C49/86; C07C50/30; C07C59/347; C07C59/353; C07C59/84; C07C69/716; C07C69/738; C07C235/74; C07C261/04; C07C309/07; C07C309/24; C07D233/72; C07D233/84; A23K1/18; C07D233/86; C07D257/04; C07D261/12; C07D305/12; C07D307/33; C07D309/12; C07D309/30; C07D309/40; C07D495/04; C07F9/09; C07F9/24; C07F9/44; (IPC1-7): C07C49/17; C07C49/245; C07C49/258; C07C49/185; A61K31/12; A61K31/122; A61K31/185; A61K31/21; A61K31/275; A61K31/095; A61K31/33; A61K31/66; A61P9/00; C07C49/82; C07C49/86; C07C49/782; C07C49/215; C07C49/723; C07C49/743; C07C49/747; C07C49/507; C07C50/30; C07C261/04; C07F9/09; C07F9/24; C07F9/44; C07C69/716; C07C69/738; C07C309/24; C07C309/07; C07C59/84; C07C59/347; C07C59/90; C07C59/50; C07C59/86; C07C59/82; C07D309/30; C07D495/04; C07D257/04; C07D261/12; C07D309/40; C07D233/72; C07D233/84; C07D233/86; C07D309/12; C07D305/12; C07D307/33
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