Title:
KINASE SUPPRESSOR OF RAS INACTIVATION FOR THERAPY OF RAS MEDIATED TUMORIGENESIS
Document Type and Number:
WIPO Patent Application WO2003101386
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided.
Inventors:
KOLESNICK RICHARD N (US)
XING HONGMEI R (US)
XING HONGMEI R (US)
Application Number:
PCT/US2003/016961
Publication Date:
October 07, 2004
Filing Date:
May 29, 2003
Export Citation:
Assignee:
SLOAN KETTERING INST CANCER (US)
KOLESNICK RICHARD N (US)
XING HONGMEI R (US)
KOLESNICK RICHARD N (US)
XING HONGMEI R (US)
International Classes:
A61K31/711; A61K48/00; A61P35/00; A61P35/02; A61P43/00; G01N33/50; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N15/09; C12N15/113; C12N15/85; C12Q1/02; G01N33/15; A61K38/00; (IPC1-7): C07H21/02; C07H21/04; C12N5/00; C12N15/00; C12N15/63; A01N63/00
Domestic Patent References:
| WO1997021820A2 | 1997-06-19 |
Other References:
ROJANASAKUL Y.: "ANTISENSE OLIGONUCLEOTIDE THERAPEUTICS: DRUG DELIVERY AND TARGETING", ADVANCED DRUG DELIVERY REVIEWS, vol. 18, 1996, pages 115 - 131, XP002913878
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