Title:
KIT INHIBITORS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/029489
Kind Code:
A1
Abstract:
Provided herein are compounds and compositions useful in inhibiting a receptor tyrosine kinase, KIT. The compounds and compositions provided herein are useful for the prevention or treatment of one or more KIT mediated diseases or conditions (e.g., cancers, autoimmune diseases, allergic diseases, inflammatory diseases, fibrosis, metabolic disorders, and neurodegenerative diseases).
More Like This:
| WO/2017/076484 | 1,4-DICARBONYL-PIPERIDYL DERIVATIVES |
| JPH04134074 | TRIAZOLE DISULFIDE DERIVATIVE |
| WO/1995/020763 | PIPERIDINE ANALOGS AND CONJUGATES OF PROCAINAMIDE AND NAPA |
Inventors:
TAKAHASHI TAISUKE (JP)
SHIMIZU TAKAFUMI (JP)
TERADA YOH (JP)
URAKAMI TAKEO (JP)
SINKO WILLIAM (US)
PODDUTOORI RAMULU (IN)
GUMMADI VENKATESHWAR RAO (IN)
SHIMIZU TAKAFUMI (JP)
TERADA YOH (JP)
URAKAMI TAKEO (JP)
SINKO WILLIAM (US)
PODDUTOORI RAMULU (IN)
GUMMADI VENKATESHWAR RAO (IN)
Application Number:
PCT/JP2023/027945
Publication Date:
February 08, 2024
Filing Date:
July 31, 2023
Export Citation:
Assignee:
MODULUS DISCOVERY INC (JP)
International Classes:
C07D401/12; A61K31/4166; A61K31/427; A61K31/437; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/497; A61K31/506; A61P3/00; A61P3/10; A61P25/00; A61P25/16; A61P29/00; A61P35/00; A61P37/00; A61P37/08; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D417/12; C07D471/04
Domestic Patent References:
| WO2005021531A1 | 2005-03-10 |
Other References:
MARYAM ABBASPOUR BABAEI ET AL: "Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. 10, 1 August 2016 (2016-08-01), pages 2443 - 2459, XP055484967, DOI: 10.2147/DDDT.S89114
PATHANIA SHELLY ET AL: "A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitors", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1876, no. 2, 1 October 2021 (2021-10-01), XP086861322, ISSN: 0304-419X, [retrieved on 20211001], DOI: 10.1016/J.BBCAN.2021.188631
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 September 2020 (2020-09-02), XP002810304, Database accession no. 2469172-88-9
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 September 2020 (2020-09-01), XP002810305, Database accession no. 2468593-56-6
VALENT ET AL., THERANOSTICS, vol. 10, no. 23, 2020, pages 10743
TURNER ET AL., BLOOD, vol. 80, 1992, pages 374 - 381
HEINRICH ET AL., J CLIN ONCOL, vol. 20, 2002, pages 1692 - 1703
HIROTA ET AL., SCIENCE (WASH DC, vol. 279, 1998, pages 577 - 580
HEINRICH ET AL.: "SCF with small molecule inhibitors or specific antibodies can also affect the function of healthy and carcinogenic cells expressing KIT receptor", PHARMACOLOGICAL INHIBITION OF KIT, 2002
VALENT ET AL., J ALLERGY CLIN IMMUNOL, vol. 149, 2022, pages 1866 - 74
TSAI M ET AL., J. ALLERGY CLIN. IMMUNOL., vol. 149, 2022, pages 1845 - 54
LENNARTSSON J ET AL., STEM CELLS, vol. 23, 2005, pages 16 - 43
CERNY-REITERER S ET AL., ONCOTARGET, vol. 6, 2015, pages 3071 - 84
CAHILL KN ET AL., N ENGL J MED, vol. 376, 2017, pages 1911 - 20
S. M. BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
"Handbook of Pharmaceutical Excipients", 2005, PHARMACEUTICAL PRESS
"Remington's Pharmaceutical Sciences", 2003, MACK PUBLISHING CO.
"The United States Pharmacopeia: The National Formulary", 1999
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", PERGAMON
PATHANIA SHELLY ET AL: "A holistic view on c-Kit in cancer: Structure, signaling, pathophysiology and its inhibitors", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1876, no. 2, 1 October 2021 (2021-10-01), XP086861322, ISSN: 0304-419X, [retrieved on 20211001], DOI: 10.1016/J.BBCAN.2021.188631
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 September 2020 (2020-09-02), XP002810304, Database accession no. 2469172-88-9
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 September 2020 (2020-09-01), XP002810305, Database accession no. 2468593-56-6
VALENT ET AL., THERANOSTICS, vol. 10, no. 23, 2020, pages 10743
TURNER ET AL., BLOOD, vol. 80, 1992, pages 374 - 381
HEINRICH ET AL., J CLIN ONCOL, vol. 20, 2002, pages 1692 - 1703
HIROTA ET AL., SCIENCE (WASH DC, vol. 279, 1998, pages 577 - 580
HEINRICH ET AL.: "SCF with small molecule inhibitors or specific antibodies can also affect the function of healthy and carcinogenic cells expressing KIT receptor", PHARMACOLOGICAL INHIBITION OF KIT, 2002
VALENT ET AL., J ALLERGY CLIN IMMUNOL, vol. 149, 2022, pages 1866 - 74
TSAI M ET AL., J. ALLERGY CLIN. IMMUNOL., vol. 149, 2022, pages 1845 - 54
LENNARTSSON J ET AL., STEM CELLS, vol. 23, 2005, pages 16 - 43
CERNY-REITERER S ET AL., ONCOTARGET, vol. 6, 2015, pages 3071 - 84
CAHILL KN ET AL., N ENGL J MED, vol. 376, 2017, pages 1911 - 20
S. M. BERGE ET AL., J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
"Handbook of Pharmaceutical Excipients", 2005, PHARMACEUTICAL PRESS
"Remington's Pharmaceutical Sciences", 2003, MACK PUBLISHING CO.
"The United States Pharmacopeia: The National Formulary", 1999
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", PERGAMON
Attorney, Agent or Firm:
OIKAWA Shu et al. (JP)
Download PDF:
Previous Patent: SWITCH DEVICE
Next Patent: REFLECTIVE-TYPE OPTICAL SCALE FOR ENCODER, REFLECTIVE-TYPE OPTICAL ENCODER, METHOD FOR MANUFACTURING...
Next Patent: REFLECTIVE-TYPE OPTICAL SCALE FOR ENCODER, REFLECTIVE-TYPE OPTICAL ENCODER, METHOD FOR MANUFACTURING...