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Title:
KRAS MUTANT PROTEIN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061333
Kind Code:
A1
Abstract:
Provided are a compound of formula I having KRas inhibitory activity, a pharmaceutical composition comprising the compound, a preparation method therefor, and use thereof. The compound has remarkable selectivity, inhibitory activity, and better medicinal prospects.

Inventors:
YIN LEI (CN)
LIU XIAOJING (CN)
Application Number:
PCT/CN2023/120527
Publication Date:
March 28, 2024
Filing Date:
September 21, 2023
Export Citation:
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Assignee:
GAN & LEE PHARM CO LTD (CN)
International Classes:
C07D471/04; A61K31/4375; A61K31/519; A61P35/00; C07D487/04; C07D487/08
Domestic Patent References:
WO2023020519A12023-02-23
WO2022247760A12022-12-01
WO2023138583A12023-07-27
WO2023020523A12023-02-23
WO2023143312A12023-08-03
WO2022256459A12022-12-08
WO2023284537A12023-01-19
WO2022042630A12022-03-03
WO2022132200A12022-06-23
WO2021041671A12021-03-04
WO2022002102A12022-01-06
WO2022105859A12022-05-27
WO2022184178A12022-09-09
Foreign References:
CN115974896A2023-04-18
CN115073451A2022-09-20
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