Title:
L-ARGININE IN COMBINATION WITH OTHER COMPOUNDS FOR TREATING CARDIOVASCULAR DISEASES
Document Type and Number:
WIPO Patent Application WO2001054686
Kind Code:
A3
Abstract:
The present invention is directed to compositions comprising: (a) a first component selected from the group consisting of L-arginine, polypeptides thereof, acceptable salts thereof, pro-forms thereof, and mixtures thereof; and (b) a second component selected from the group consisting of sterols, stanols, esters thereof, polyol fatty acid polyesters, and mixtures thereof. The present invention is further directed to kits comprising these compositions as well as methods of using the compositions. The compositions, kits, and methods herein are useful for providing general health benefits to the consumer, particularly cardiovascular benefits, anti-menopausal benefits and/or treating sexual dysfunction (particularly, erectile dysfunction). Most particularly, the compositions, kits, and methods herein are useful for providing cardiovascular benefits, including lowering cholesterol in the consumer, treating, preventing, and/or inhibiting heart disease (e.g., atherosclerosis, restenosis, thrombosis) and, for example, treating other conditions such as hypercholesterolemia, hypertension, poor circulation, and complications associated with diabetes.
Inventors:
SARAMA ROBERT JOSEPH (US)
NIEHOFF RAYMOND LOUIS (US)
NIEHOFF RAYMOND LOUIS (US)
Application Number:
PCT/US2001/002382
Publication Date:
May 02, 2002
Filing Date:
January 25, 2001
Export Citation:
Assignee:
PROCTER & GAMBLE (US)
SARAMA ROBERT JOSEPH (US)
NIEHOFF RAYMOND LOUIS (US)
SARAMA ROBERT JOSEPH (US)
NIEHOFF RAYMOND LOUIS (US)
International Classes:
A61K47/26; A61K31/198; A61K38/00; A61K45/06; A61K47/28; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; (IPC1-7): A61K31/195; A61K31/23; A61K31/575; A61P9/00
Foreign References:
| DE19800812A1 | 1999-07-15 | |||
| US5157022A | 1992-10-20 | |||
| DE19750422C1 | 1998-11-26 |
Other References:
YASMIN A. ET AL.: "Chemical composition of Cassia holosericae", J. PHARM. UNIVERSITY OF KARACHI, vol. 3, no. 2, 1985, pages 101 - 104, XP001000550
FRASER G E: "DIET AND CORONARY HEART DISEASE: BEYOND DIETARY FATS AND LOW-DENSITY-LIPOPROTEIN CHOLESTEROL1-3", AMERICAN JOURNAL OF CLINICAL NUTRITION,BETHESDA,MD,US, vol. 59, no. SUPPL, 1994, pages 1117S - 1123S, XP000999672, ISSN: 0002-9165
FRASER G E: "DIET AND CORONARY HEART DISEASE: BEYOND DIETARY FATS AND LOW-DENSITY-LIPOPROTEIN CHOLESTEROL1-3", AMERICAN JOURNAL OF CLINICAL NUTRITION,BETHESDA,MD,US, vol. 59, no. SUPPL, 1994, pages 1117S - 1123S, XP000999672, ISSN: 0002-9165
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