L-CYSTEINE-PRODUCING BACTERIUM, AND PROCESS FOR PRODUCTION OF L-CYSTEINE

WIPO Patent Application WO/2011/065469

A1

A novel technique for improving the L-cysteine-producing ability of a bacterium is developed. Thus, disclosed are: an L-cysteine-producing bacterium; and a process for producing a compound such as L-cysteine using the bacterium. L-Cysteine, L-cystine or a derivative thereof can be produced by culturing a bacterium that is capable of producing L-cysteine, belongs to the family Enterobacteriaceae and has been so modified that the activity of a protein encoded by yciW gene (e.g., a protein mentioned in item (A) or (B)) is reduced, in a culture medium, and collecting any one of the compounds or a mixture thereof from the culture medium. (A) A protein which has the amino acid sequence represented by SEQ ID NO:2. (B) A protein which has an amino acid sequence produced by substituting, deleting, inserting or adding one or a few amino acid residues in the amino acid sequence represented by SEQ ID NO:2, and which has such a characteristic property that the L-cysteine production ability of the bacterium is improved when the activity of the protein is decreased in the bacterium.

JPH07102152	INDUSTRIAL APPLICABILITY: Method for producing desired polypeptide
JP2008509117	HAI-1 and HAI-2 in cancer treatment
WO/2016/014240	COMPOSITIONS AND METHODS FOR THE DETECTION AND ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS

NONAKA GEN (JP)

PCT/JP2010/071102

June 03, 2011

November 26, 2010

Click for automatic bibliography generation  

AJINOMOTO KK (JP)
NONAKA GEN (JP)

C12N15/09; C12N1/21; C12P13/12

WO2002077183A2	2002-10-03
WO2001027307A1	2001-04-19
WO1997015673A1	1997-05-01
WO2005007841A1	2005-01-27
WO2005010175A1	2005-02-03
WO2007119880A1	2007-10-25
WO2006093322A2	2006-09-08

JPH11155571A	1999-06-15
JPH06510911A	1994-12-08
JP2002233384A	2002-08-20
JPH11155571A	1999-06-15
US20050112731A1	2005-05-26
US6218168B1	2001-04-17
JP2003169668A	2003-06-17
JP2005245311A	2005-09-15
US5972663A	1999-10-26
JP2005287333A	2005-10-20
US5856148A	1999-01-05
US20050009162A1	2005-01-13
JP2992010B2	1999-12-20
EP0952221A2	1999-10-27
US6596517B2	2003-07-22
JP2004049237A	2004-02-19
JP2005137369A	2005-06-02
EP1528108A1	2005-05-04
EP1016710A2	2000-07-05
US20050124049A1	2005-06-09
EP1528108A1	2005-05-04
US20050112731A1	2005-05-26
JPH02109985A	1990-04-23
JP2000139471A	2000-05-23
US20090029424A1	2009-01-29
US20080311632A1	2008-12-18
GB2075055A	1981-11-11
RU2209248C2	2003-07-27
RU2215782C2	2003-11-10
JP2003010654A	2003-01-14
JP2005168422A	2005-06-30
EP0647712A1	1995-04-12
EP1457569A1	2004-09-15
US7410789B2	2008-08-12
US6303383B1	2001-10-16
JPH057491A	1993-01-19
JP2005058227A	2005-03-10
US20060154344A1	2006-07-13
US6180373B1	2001-01-30

DASSLER, T. ET AL.: "Identification of a major facilitator protein from Escherichia coli involved in efflux of metabolites of the cysteine pathway.", MOL MICROBIOL., vol. 36, no. 5, 2000, pages 1101 - 1112, XP000992212
GYANESHWAR, P. ET AL.: "Sulfur and nitrogen limitation in Escherichia coli K-12: specific homeostatic responses.", J BACTERIOL., vol. 187, no. 3, 2005, pages 1074 - 1090, XP002418950
MILLER, EN. ET AL.: "Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180.", APPL ENVIRON MICROBIOL., vol. 75, no. 19, October 2009 (2009-10-01), pages 6132 - 6141, XP002584225
WANG, S. ET AL.: "Transcriptomic response of Escherichia coli 0157:H7 to oxidative stress.", APPL ENVIRON MICROBIOL., vol. 75, no. 19, October 2009 (2009-10-01), pages 6110 - 6123, XP008157433
DABLER ET AL., MOL. MICROBIOL., vol. 36, 2000, pages 1101 - 1112
GYANESHWAR, P. ET AL., J. BACTERIOL., vol. 187, 2005, pages 1074 - 1090
ELLIOT N.; MILLER, E.N. ET AL., APPL. ENVIR. MICROBIOL., 2009
WANG, S. ET AL., APPL. ENVIR. MICROBIOL., 2009
SZCZEPKOWSKI T.W., NATURE, vol. 182, 1958
BACKMANN B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology/Second Edition", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
J. GEN. APPL. MICROBIOL., vol. 43, no. 6, December 1997 (1997-12-01), pages 355 - 361
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, October 1997 (1997-10-01), pages 1061 - 1067
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 39, no. 3, July 1989 (1989-07-01), pages 337 - 345
JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 43, no. 1, January 1993 (1993-01-01), pages 162 - 173
"Amino Acid Fermentation", 30 May 1986, GAKKAI SHUPPAN CENTER (LTD., pages: 77 - 100
CHANDRA ET AL., BIOCHEMISTRY, vol. 21, 1982, pages 3064 - 3069
NEWTON ET AL., J. BIOL. CHEM., vol. 240, 1965, pages 1211 - 1218
DENK, D.; BOECK, A., J. GENERAL MICROBIOL., vol. 133, 1987, pages 515 - 525
FEMS MICROBIOL. LETT., vol. 179, 1999, pages 453 - 459
D.A. MORRISON, METHODS IN ENZYMOLOGY, vol. 68, 1979, pages 326
MANDEL, M.; HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159
YIRI LI; GONGYUAN WEI; JIAN CHEN, APPL. MICROBIOL. BIOTECHNOL., vol. 66, 2004, pages 233 - 242
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 8611 - 8617
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 95, 1998, pages 5511 - 5515
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, 1991, pages 20833 - 20839
DATSENKO, K.A; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
CHO, E.H.; GUMPORT, R.I.; GARDNER, J.F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
"Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Molecular cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
DATSENKO; WANNER, PROC. NATL. ACAD. SCI. USA, vol. 97, no. 12, 2000, pages 6640 - 6645
GAITONDE, M.K., BIOCHEM. J., vol. 104, no. 2, August 1967 (1967-08-01), pages 627 - 33

KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)

View/Download PDF      PDF Help

Previous Patent: ROTATION TOOL

Next Patent: ELECTRICAL ACTUATOR