Title:
L-N-ISOBUTYRYL CYSTEINE (L-NIBC) -BOUND GOLD CLUSTER AU 15 (L-NIBC) 13, COMPOSITIONS AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/137671
Kind Code:
A1
Abstract:
L-N-isobutyryl cysteine (L-NIBC) -bound gold cluster Au 15 (L-NIBC) 13, its use for treating multiple sclerosis, Alzheimer's disease (AD), liver cirrhosis, diabetes, Parkinson's disease (PD) or glaucoma, and the use of it for manufacturing a medicament for treatment of multiple sclerosis, Alzheimer's disease (AD), liver cirrhosis, diabetes, Parkinson's disease (PD) or glaucoma. Composition and methods for treating multiple sclerosis, Alzheimer's disease (AD), liver cirrhosis, diabetes, Parkinson's disease (PD) or glaucoma.
Inventors:
SUN TAOLEI (CN)
Application Number:
PCT/CN2022/073050
Publication Date:
July 27, 2023
Filing Date:
January 20, 2022
Export Citation:
Assignee:
SHENZHEN PROFOUND VIEW PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
A61K47/69; A61P1/16; A61P3/00; A61P25/00; A61P25/16; A61P25/28; A61P27/06
Domestic Patent References:
| WO2021184762A1 | 2021-09-23 | |||
| WO2021072747A1 | 2021-04-22 | |||
| WO2021128292A1 | 2021-07-01 |
Foreign References:
| EP3545948A1 | 2019-10-02 | |||
| EP3449945A1 | 2019-03-06 |
Other References:
CYRILLE GAUTIER ET AL: "Chiral N -Isobutyryl-cysteine Protected Gold Nanoparticles: Preparation, Size Selection, and Optical Activity in the UV−vis and Infrared", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, no. 34, 1 August 2006 (2006-08-01), pages 11079 - 11087, XP055672619, ISSN: 0002-7863, DOI: 10.1021/ja058717f
YUICHI NEGISHI ET AL: "Glutathione-Protected Gold Clusters Revisited: Bridging the Gap between Gold(I)−Thiolate Complexes and Thiolate-Protected Gold Nanocrystals", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 14, 1 April 2005 (2005-04-01), pages 5261 - 5270, XP055000542, ISSN: 0002-7863, DOI: 10.1021/ja042218h
TLAHUICE-FLORES ALFREDO ET AL: "On the structure of the thiolated Au15 cluster", PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 15, no. 45, 1 January 2013 (2013-01-01), pages 19557 - 19560, XP055932414, ISSN: 1463-9076, Retrieved from the Internet DOI: 10.1039/c3cp53837k
TLAHUICE-FLORES ALFREDO ED - WANG RONGMING ET AL: "Ligand effects on the structure and vibrational properties of the thiolated Au18cluster", PROGRESS IN NATURAL SCIENCE: MATERIALS INTERNATIONAL, vol. 26, no. 5, 13 October 2016 (2016-10-13), pages 510 - 515, XP029803896, ISSN: 1002-0071, DOI: 10.1016/J.PNSC.2016.09.008
YUICHI NEGISHI ET AL: "Glutathione-Protected Gold Clusters Revisited: Bridging the Gap between Gold(I)−Thiolate Complexes and Thiolate-Protected Gold Nanocrystals", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, no. 14, 1 April 2005 (2005-04-01), pages 5261 - 5270, XP055000542, ISSN: 0002-7863, DOI: 10.1021/ja042218h
TLAHUICE-FLORES ALFREDO ET AL: "On the structure of the thiolated Au15 cluster", PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 15, no. 45, 1 January 2013 (2013-01-01), pages 19557 - 19560, XP055932414, ISSN: 1463-9076, Retrieved from the Internet
TLAHUICE-FLORES ALFREDO ED - WANG RONGMING ET AL: "Ligand effects on the structure and vibrational properties of the thiolated Au18cluster", PROGRESS IN NATURAL SCIENCE: MATERIALS INTERNATIONAL, vol. 26, no. 5, 13 October 2016 (2016-10-13), pages 510 - 515, XP029803896, ISSN: 1002-0071, DOI: 10.1016/J.PNSC.2016.09.008
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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