Title:
L-STEPHOLIDINE (L-SPD) DERIVATIVES, PREPARATION METHOD AND USAGE THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/128431
Kind Code:
A1
Abstract:
The invention relates to l-stepholidine (l-SPD) derivant described as general formula (I) and its producing method. Said l-SPD derivatives and pharmacological acceptable salts, crystalline hydrates, solvates thereof have a double pharmacological effects of dopamine receptor D1 agonistic-D2 antagonistic in global cerebra and have a good physicochemical property and oral bioavailability and can be used to prepare the medicine for treating human or animal nervous system diseases, especially for schizophrenosis and other dopamine receptor correlated nervous system diseases.
Inventors:
ZHEN XUECHU (CN)
CHENG JIANJUN (CN)
GUO YANG (CN)
MO JIAO (CN)
YANG YUSHE (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
CHENG JIANJUN (CN)
GUO YANG (CN)
MO JIAO (CN)
YANG YUSHE (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
Application Number:
PCT/CN2008/000795
Publication Date:
October 30, 2008
Filing Date:
April 17, 2008
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
ZHEN XUECHU (CN)
CHENG JIANJUN (CN)
GUO YANG (CN)
MO JIAO (CN)
YANG YUSHE (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
ZHEN XUECHU (CN)
CHENG JIANJUN (CN)
GUO YANG (CN)
MO JIAO (CN)
YANG YUSHE (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
International Classes:
C07D455/03; A61K31/4375; A61P25/00; A61P25/18
Foreign References:
| CN1900076A | 2007-01-24 | |||
| CN1900075A | 2007-01-24 | |||
| CN1603324A | 2005-04-06 | |||
| CN101037436A | 2007-09-19 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B Kingsound International center, 116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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