Title:
L-STEPHOLIDINE SUSTAINED RELEASE MICROSPHERE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/228585
Kind Code:
A1
Abstract:
A method for preparing a l-stepholidine sustained-release microsphere, comprising the following steps: dissolving l-stepholidine and a degradable polymer having a hydrophobic chain segment in an organic solvent to obtain a drug-containing polymer solution; adding the drug-containing polymer solution to an aqueous phase while stirring to form an 0/W emulsion, and removing the organic solvent therefrom; the aqueous phase contains a stabilizer, and the ratio of the stabilizer to the aqueous phase is 0.1% to 5% (w/v); and while stirring, adding the above obtained dispersion system to water for curing, so as to obtain an l-stepholidine sustained-release microsphere having a good particle size, a round shape, no sudden release, and a long-acting antidepressant effect.
Inventors:
ZHEN XUECHU (CN)
CAO QINGRI (CN)
HE LIYA (CN)
CAO QINGRI (CN)
HE LIYA (CN)
Application Number:
PCT/CN2022/095853
Publication Date:
November 03, 2022
Filing Date:
May 30, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K9/16; A61K31/4375; A61K47/34; A61P25/18
Foreign References:
| CN113384537A | 2021-09-14 | |||
| CN108703968A | 2018-10-26 | |||
| CN110237052A | 2019-09-17 | |||
| CN109718225A | 2019-05-07 | |||
| US20130224257A1 | 2013-08-29 |
Other References:
LI XUN 、, WEI YI;MA GUANGHUI;HU LINLIN: "Recent research and development prospects for sustained-release microspheres", JOURNAL OF BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY (NATURAL SCIENCE EDITION), BEIJING HUAGONG DAXUE, CN, vol. 44, no. 6, 20 November 2017 (2017-11-20), CN , pages 1 - 11, XP055982856, ISSN: 1671-4628, DOI: 10.13543/j.bhxbzr.2017.06.001
Attorney, Agent or Firm:
HERUN-KESHENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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