Title:
LACTOBACILLUS PLANTARUM HAVING IMPROVEMENT EFFECT ON CEREBRAL STROKE
Document Type and Number:
WIPO Patent Application WO/2021/174800
Kind Code:
A1
Abstract:
Provided is a Lactobacillus plantarum AR113 strain having improvement effect on cerebral stroke, with an accession number of CGMCC No.13909. The Lactobacillus plantarum AR113 strain can increase the antioxidant enzyme activity of brain tissues, reduce the level of oxidation products, activate the Nrf-ARE signal pathway, and regulate the relative expression of antioxidant factors Nrf2, NQO-1, and HO-1, and can also down-regulate the mRNA expression of pro-apoptotic factors Cyt-C, Caspase-3, and Bax, and up-regulate the relative expression of anti-apoptotic factor Bcl-2, thereby improving brain cell damage caused by cerebral ischemia reperfusion.
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Inventors:
AI LIANZHONG (CN)
XIONG ZHIQIANG (CN)
XIA YONGJUN (CN)
WANG GUANGQIANG (CN)
ZHANG HUI (CN)
LAI FENGXI (CN)
SONG XIN (CN)
XIONG ZHIQIANG (CN)
XIA YONGJUN (CN)
WANG GUANGQIANG (CN)
ZHANG HUI (CN)
LAI FENGXI (CN)
SONG XIN (CN)
Application Number:
PCT/CN2020/114637
Publication Date:
September 10, 2021
Filing Date:
September 11, 2020
Export Citation:
Assignee:
UNIV OF SHANGHAI FOR SCIENCE AND TECHNOLOGY (CN)
International Classes:
C12N1/20; A61K35/747; A61P9/10; A61P25/00; C12R1/25
Foreign References:
| CN111394276A | 2020-07-10 | |||
| CN110423710A | 2019-11-08 | |||
| CN110468050A | 2019-11-19 |
Other References:
FANG LING, XIA YONGJUN, LIU GANG, AI LIANZHONG, XIONG ZHIQIANG: "Oral Application Characteristics of Two Lactobacillus plantarum", SHIPIN YU FAJIAO KEJI - SICHUAN FOOD AND FERMENTATION, SICHUAN SHENG SHIPIN FAJIAO GONGYE YANJIU SHEJIYUAN, CN, vol. 55, no. 2, 30 April 2019 (2019-04-30), CN, pages 68 - 72, XP055841912, ISSN: 1674-506X, DOI: 10.3969/j.issn.1674-506X.2019.03-013
AKHOUNDZADEH KOBRA, VAKILI ABEDIN, SHADNOUSH MAHDI, SADEGHZADEH JAFAR: "Effects of the Oral Ingestion of Probiotics on Brain Damage in a Transient Model of Focal Cerebral Ischemia in Mice", IRANIAN JOURNAL OF MEDICAL SCIENCES, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, IRAN, 1 January 2018 (2018-01-01), Iran, pages 32 - 40, XP055841913, Retrieved from the Internet [retrieved on 20210916]
AKHOUNDZADEH KOBRA, VAKILI ABEDIN, SHADNOUSH MAHDI, SADEGHZADEH JAFAR: "Effects of the Oral Ingestion of Probiotics on Brain Damage in a Transient Model of Focal Cerebral Ischemia in Mice", IRANIAN JOURNAL OF MEDICAL SCIENCES, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, IRAN, 1 January 2018 (2018-01-01), Iran, pages 32 - 40, XP055841913, Retrieved from the Internet
Attorney, Agent or Firm:
SHANGHAI DANRONG & ZONGDE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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