Title:
LARGE AND SMALL T ANTIGENS OF MERKEL CELL POLYOMAVIRUS, NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/143921
Kind Code:
A3
Abstract:
Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Merkel Cell Polyomavirus (MCV) T antigen. Immunomodulatory methods and methods of inducing an immune response against MCV are disclosed. Method of treating infection by MCV and methods of treating or preventing Merkel Cell Carcinoma associated with MCV are disclosed. Modified consensus MCV T antigens are disclosed.
Inventors:
WEINER DAVID (US)
DUPERRET ELIZABETH (US)
DUPERRET ELIZABETH (US)
Application Number:
PCT/US2019/014171
Publication Date:
April 09, 2020
Filing Date:
January 18, 2019
Export Citation:
Assignee:
WISTAR INST (US)
International Classes:
A61K39/00; A61K38/16; A61K39/12; A61P35/00; C07K14/01; C07K14/025
Domestic Patent References:
| WO2016073595A1 | 2016-05-12 | |||
| WO2016193389A1 | 2016-12-08 |
Foreign References:
| US20020123099A1 | 2002-09-05 |
Other References:
KWUN ET AL.: "Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen", J VIROL, vol. 89, 28 January 2015 (2015-01-28), pages 4191 - 4200, XP055700168
SHUDA ET AL.: "Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator", J CLIN INVEST, vol. 121, no. 9, 15 August 2011 (2011-08-15), pages 3623 - 3634, XP055700171
SHUDA ET AL.: "Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator", J CLIN INVEST, vol. 121, no. 9, 15 August 2011 (2011-08-15), pages 3623 - 3634, XP055700171
Attorney, Agent or Firm:
NGUYEN, Quang, D. et al. (US)
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