Title:
LAYERED SUPER-HYDROPHILIC TI-CU-MOFS AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/147730
Kind Code:
A1
Abstract:
The present invention provides layered super-hydrophilic Ti-Cu-MOFs and a preparation method and application thereof, and relates to the technical field of composite materials. In the present invention, copper ions and titanium ions are used as bimetallic centers and undergo a coordination reaction with rigid aromatic amine ligands, thus efficiently synthesizing layered super-hydrophilic Ti-Cu-MOFs having a lamellar structure. Compared with the prior art, the preparation method of the present invention is simple, can control shape and structure, prepares layered super-hydrophilic Ti-Cu-MOFs having surfaces rich in hydroxyl groups, has a high adsorption capacity for phospholipid co-extracts in clinical biological samples, and can be used for analyzing phenothiazine drugs and metabolites thereof in biological samples and for realizing one-step separation and purification, thus greatly improving the pretreatment efficiency of clinical biological samples and shortening analysis time.
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Inventors:
LU YIN (CN)
ZHAO YONGGANG (CN)
LEI CHAO (CN)
YE MINGLI (CN)
SAVISKAYA TAZIANA (CN)
IVANIC ANDREI (CN)
ZHAO YONGGANG (CN)
LEI CHAO (CN)
YE MINGLI (CN)
SAVISKAYA TAZIANA (CN)
IVANIC ANDREI (CN)
Application Number:
PCT/CN2022/124858
Publication Date:
August 10, 2023
Filing Date:
October 12, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG SHUREN (CN)
International Classes:
C08G83/00; B01J20/281
Foreign References:
| CN114479108A | 2022-05-13 | |||
| CN113398876A | 2021-09-17 | |||
| CN104280484A | 2015-01-14 | |||
| CN108421531A | 2018-08-21 | |||
| US5763658A | 1998-06-09 |
Other References:
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MENG, YING: "Study on Metal-Organic Framework Y(BTC)(H2O)6 in the Isolation and Purification of Hemoglobin", CHINESE MASTER’S DISSERTATIONS FULL-TEXT DATABASE (ELECTRONIC JOURNAL), no. 12, 15 December 2018 (2018-12-15)
SONG YI PING; LI NAN; ZHANG HUI CAI; WANG GENG NAN; LIU JU XIANG; LIU JING; WANG JIAN PING: "Dummy template molecularly imprinted polymer for solid phase extraction of phenothiazines in meat based on computational simulation", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 233, 26 April 2017 (2017-04-26), NL , pages 422 - 428, XP085491865, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2017.04.146
XIA WAN QIU, CUI PENG LEI, WANG GENG NAN, LIU JING, WANG JIAN PING: "Application of dual-template molecularly imprinted polymer-based solid phase extraction for determination of phenothiazines and benzodiazepines in swine feed", ANALYTICAL METHODS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 10, no. 25, 1 January 2018 (2018-01-01), GB , pages 3001 - 3010, XP093082302, ISSN: 1759-9660, DOI: 10.1039/C8AY00873F
WANG WENXUE: "Determination of Plasma Concentration of Chlorpromazine Hydrochloride by Solid Phase Extraction and High Performance Liquid Chromatography", CHINESE JOURNAL OF HOSPITAL PHARMACY, ZHONGGUO YAO XUEHUI WUHAN FENHUI, WUHAN, CN, vol. 32, no. 16, 12 December 2012 (2012-12-12), CN , pages 1313 - 1314, XP093082301, ISSN: 1001-5213, DOI: 10.13286/j.cnki.chinhosppharmacyj.2012.16.027
MENG, YING: "Study on Metal-Organic Framework Y(BTC)(H2O)6 in the Isolation and Purification of Hemoglobin", CHINESE MASTER’S DISSERTATIONS FULL-TEXT DATABASE (ELECTRONIC JOURNAL), no. 12, 15 December 2018 (2018-12-15)
SONG YI PING; LI NAN; ZHANG HUI CAI; WANG GENG NAN; LIU JU XIANG; LIU JING; WANG JIAN PING: "Dummy template molecularly imprinted polymer for solid phase extraction of phenothiazines in meat based on computational simulation", FOOD CHEMISTRY, ELSEVIER LTD., NL, vol. 233, 26 April 2017 (2017-04-26), NL , pages 422 - 428, XP085491865, ISSN: 0308-8146, DOI: 10.1016/j.foodchem.2017.04.146
XIA WAN QIU, CUI PENG LEI, WANG GENG NAN, LIU JING, WANG JIAN PING: "Application of dual-template molecularly imprinted polymer-based solid phase extraction for determination of phenothiazines and benzodiazepines in swine feed", ANALYTICAL METHODS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 10, no. 25, 1 January 2018 (2018-01-01), GB , pages 3001 - 3010, XP093082302, ISSN: 1759-9660, DOI: 10.1039/C8AY00873F
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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