Title:
LEUKOTRIENE B4 ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO1992000011
Kind Code:
A3
Abstract:
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof +TR wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R1 is alkyl; R2 is hydrogen, alkyl; R6 is alkyl; n is 1 to 5; p is 0 to 6; x is 0 or 2; and R4 and R5 are independently hydrogen or alkyl or together with N form a cycloalkylamine. The compounds of Formula I are leukotriene B4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB4.
Inventors:
DJURIC STEVAN WAKEFIELD (US)
DOCTER STEPHEN HERMANN (US)
YU STELLA SIU-TZYY (US)
DOCTER STEPHEN HERMANN (US)
YU STELLA SIU-TZYY (US)
Application Number:
PCT/US1991/004386
Publication Date:
February 06, 1992
Filing Date:
June 27, 1991
Export Citation:
Assignee:
SEARLE & CO (US)
International Classes:
A61K31/00; A61K31/19; A61K31/192; A61K31/22; A61K31/222; A61K31/35; A61K31/352; A61K31/353; A61K31/40; A61P29/00; A61P43/00; C07C235/60; C07D295/192; C07D311/58; C07D311/66; (IPC1-7): A61K31/40; A61K31/165
Foreign References:
| US4889871A | 1989-12-26 | |||
| EP0336068A1 | 1989-10-11 | |||
| US4565882A | 1986-01-21 | |||
| EP0028063A1 | 1981-05-06 |
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