Title:
LEUKOTRIENE B4 DERIVATIVES, IN PARTICULAR OXIMO-LTB4 ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO1998052915
Kind Code:
A3
Abstract:
PCT No. PCT/EP98/03139 Sec. 371 Date Mar. 27, 2000 Sec. 102(e) Date Mar. 27, 2000 PCT Filed May 22, 1998 PCT Pub. No. WO98/52915 PCT Pub. Date Nov. 26, 1998Leukotriene-B4 derivatives of general formula (I), in which R1 represents H, CF3, CH2OH, and R2 represents H or an organic acid radical; R3 symbolizes H, C1-C14 alkyl, C3-C10 cycloalkyl, or a 5- to 6-membered aromatic heterocyclic ring with at least 1 heteroatom; R4 means hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl; A symbolizes a trans, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group; B symbolizes a C1-C10- straight-chain or branched-chain alkylene group or group (a) or (b); D can mean a direct bond, oxygen, sulfur, -C 3BOND C-, -CH=CR7, or together with B can also mean a direct bond; R5 and R6 are the same or different and represent H or C1-C4 alkyl, or R6 represents H and R5 represents C1-C15 alkanoyl or R8 represents SO2; R7 means H, C1-C5 alkyl, chlorine, bromine; R8 has the same meaning as R3, m means 1-3, o means 0-5, p means 0-5, X is a direct bond, oxygen, sulfur, an aromatic compound or heteroaromatic compound, Y is a C1-C8 alkyl, C3-C10 cycloalkyl, n is 2-5, and, if R4 means hydrogen, their salts with physiologically compatible bases and their cyclodextrin clathrates. The leukotriene derivatives are used as dermatological products.
Inventors:
BUCHMANN BERND (DE)
FROEHLICH WOLFGANG (DE)
GIESEN CLAUDIA (DE)
HENNEKES HARTWIG (DE)
JAROCH STEFAN (DE)
SKUBALLA WERNER (DE)
FROEHLICH WOLFGANG (DE)
GIESEN CLAUDIA (DE)
HENNEKES HARTWIG (DE)
JAROCH STEFAN (DE)
SKUBALLA WERNER (DE)
Application Number:
PCT/EP1998/003139
Publication Date:
February 25, 1999
Filing Date:
May 22, 1998
Export Citation:
Assignee:
SCHERING AG (DE)
BUCHMANN BERND (DE)
FROEHLICH WOLFGANG (DE)
GIESEN CLAUDIA (DE)
HENNEKES HARTWIG (DE)
JAROCH STEFAN (DE)
SKUBALLA WERNER (DE)
BUCHMANN BERND (DE)
FROEHLICH WOLFGANG (DE)
GIESEN CLAUDIA (DE)
HENNEKES HARTWIG (DE)
JAROCH STEFAN (DE)
SKUBALLA WERNER (DE)
International Classes:
A61K31/19; A61K31/23; A61K31/557; A61K31/5575; A61P17/00; A61P29/00; A61P37/08; A61P43/00; C07C403/08; C07C405/00; C07D251/44; C07D251/50; C07D251/54; C07D251/60; C07D257/04; C07D257/06; C07D277/24; C07D277/28; C07D277/56; (IPC1-7): C07C405/00
Domestic Patent References:
| WO1995020563A1 | 1995-08-03 |
Foreign References:
| EP0581187A1 | 1994-02-02 |
Other References:
VLATTAS, ISIDOROS ET AL: "O-(1-Alkyl- or arylthioalkyl)hydroxylamines. New class of oxime reagents, their preparation, and synthetic utility", J. ORG. CHEM. (1973), 38(21), 3749-52 CODEN: JOCEAH, 1973, XP002084528
HAMANAKA, NOBUYUKI ET AL: "Molecular design of novel PGI2 agonists without PG skeleton. II", BIOORG. MED. CHEM. LETT. (1995), 5(10), 1071-6 CODEN: BMCLE8;ISSN: 0960-894X, 1995, XP002084529
HAMANAKA, NOBUYUKI ET AL: "Molecular design of novel PGI2 agonists without PG skeleton. II", BIOORG. MED. CHEM. LETT. (1995), 5(10), 1071-6 CODEN: BMCLE8;ISSN: 0960-894X, 1995, XP002084529
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