Title:
LEWIS-TYPE SUGAR CHAIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1993/015098
Kind Code:
A1
Abstract:
A novel SLe-type sugar chain derivative represented by general formula [I], which is useful as a medicine and has a novel structure containing moranoline, wherein R?1¿ represents hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R?2¿ and R?3¿ represent each independently galactosyl, sialylgalactosyl or fucosyl; and R?4¿ represents hydroxy or acetamido. This compound has the activity of inhibiting cell adhesion and inhibits secretin antagonistically, thus being useful for treating inflammation and its accompanying thrombosis, asthma and rheumatism, and for preventing and treating immunopathy and cancer.
Inventors:
HASEGAWA AKIRA (JP)
KISO MAKOTO (JP)
YOSHIKUNI YOSHIAKI (JP)
KISO MAKOTO (JP)
YOSHIKUNI YOSHIAKI (JP)
Application Number:
PCT/JP1993/000106
Publication Date:
August 05, 1993
Filing Date:
January 29, 1993
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
HASEGAWA AKIRA (JP)
HASEGAWA AKIRA (JP)
International Classes:
C07H3/06; C07H17/02; (IPC1-7): C07H17/02
Foreign References:
| JPS62174095A | 1987-07-30 |
Other References:
A. HASEGAWA et al.: "Synthesis of 1-deoxy-nojirimycin-containing glycans related to the Lewis X and Sialyl-Lewis X epitopes recognized by LEC-CAMS", X carbohydrate Research, Vol. 229, No. 1, pages C1-C4, (14.05.1992), ELSVIER.
Download PDF:
Previous Patent: REAGENTS AND METHODS FOR THE DETERMINATION OF GLYCOHYDROLYTIC ENZYMES
Next Patent: WO/1993/015101
Next Patent: WO/1993/015101