Title:
LIGAND-BOUND ZINC SULFIDE NANOPARTICLES, METHODS FOR MAKING THE SAME, AND THEIR USE FOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/198438
Kind Code:
A1
Abstract:
Disclosed are ligand-bound zinc sulfide nanoparticles, the method of preparing the ligand-bound zinc sulfide nanoparticles, composition containing ligand-bound zinc sulfide nanoparticles, uses of ligand-bound zinc sulfide nanoparticles and composition containing ligand-bound zinc sulfide nanoparticles, including inhibiting the fibrosis of amyloid-β (Aβ) and reducing the expression of inflammatory factors, treatment of Aβ fibrosis-caused/related Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal ganglion cell degeneration in glaucoma (RGCD) or myositis/myopathy (MM). Preparing drugs for the treatment of AD, CAA, RGCD OR MM and methods for treating the above diseases are also disclosed.
Inventors:
SUN TAOLEI (CN)
GAO GUANBIN (CN)
YU MENG (CN)
GAO GUANBIN (CN)
YU MENG (CN)
Application Number:
PCT/CN2021/082357
Publication Date:
September 29, 2022
Filing Date:
March 23, 2021
Export Citation:
Assignee:
WUHAN VAST CONDUCT SCIENCE FOUND CO LTD (CN)
International Classes:
A61K33/30; A61K47/54; A61P9/10; A61P21/00; A61P25/28; A61P27/06; A61P29/00; A61P43/00; B82Y5/00; B82Y40/00
Domestic Patent References:
| WO2015156870A2 | 2015-10-15 | |||
| WO2020147267A1 | 2020-07-23 |
Foreign References:
| CN102765745A | 2012-11-07 | |||
| CN112494660A | 2021-03-16 | |||
| CN111035653A | 2020-04-21 |
Other References:
GARCIA-CORTES MARTA, SOTELO GONZÁLEZ EMMA, FERNÁNDEZ-ARGÜELLES MARÍA T., ENCINAR JORGE RUIZ, COSTA-FERNÁNDEZ JOSÉ M., SANZ-MEDEL A: "Capping of Mn-Doped ZnS Quantum Dots with DHLA for Their Stabilization in Aqueous Media: Determination of the Nanoparticle Number Concentration and Surface Ligand Density", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 33, no. 25, 27 June 2017 (2017-06-27), US , pages 6333 - 6341, XP055970795, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.7b00409
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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