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Title:
LIGAND-DRUG CONJUGATE OF CAMPTOTHECIN ANALOGS, INTERMEDIATES, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/207773
Kind Code:
A1
Abstract:
Provided are conjugates of novel camptothecin analogs with a cell binding molecule of formula (I). It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of application the conjugates in targeted treating of cancer.

Inventors:
YANG HONGYU (CN)
WANG XINGHAI (CN)
Application Number:
PCT/CN2023/089679
Publication Date:
November 02, 2023
Filing Date:
April 21, 2023
Export Citation:
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Assignee:
SHANGHAI MICURX PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4745; A61K31/47; A61K39/395; A61K47/68; A61P31/00; A61P35/00; C07D491/22; C07K16/00
Domestic Patent References:
WO2021212638A12021-10-28
WO2020063676A12020-04-02
Foreign References:
JP2002255821A2002-09-11
CN109106951A2019-01-01
US20100015136A12010-01-21
CN113766954A2021-12-07
Attorney, Agent or Firm:
HANQIAO PATENT (CN)
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