Title:
LIGHT-MEDIATED ANTI-CELL PROLIFERATIVE COMPOSITIONS AND METHODS
Document Type and Number:
WIPO Patent Application WO2008051612
Kind Code:
A9
Abstract:
The tumor-necrosis factor superfamily member LIGHT (p30; TNFSF- 14) is a cytokine for inducing immune responses against tumors. A novel biochemical approach is used to decorate the surface of tumor cells with LIGHT. LIGHT decorated cells can be used to vaccinate and induce effective, sustained immunity against cells expressing neo or pathogen associated antigens. Variants of LIGHT are described that enhance binding to cellular receptors (e.g., LT beta receptor) and decrease regulation by inhibitors (e.g., Decoy Receptor 3) increasing ability to stimulate immunity.
Inventors:
CHEUNG TIMOTHY C (US)
WARE CARL F (US)
BANKS THERESIA A (US)
WARE CARL F (US)
BANKS THERESIA A (US)
Application Number:
PCT/US2007/022711
Publication Date:
June 26, 2008
Filing Date:
October 25, 2007
Export Citation:
Assignee:
JOLLA INST ALLERGY IMMUNOLOG (US)
CHEUNG TIMOTHY C (US)
WARE CARL F (US)
BANKS THERESIA A (US)
CHEUNG TIMOTHY C (US)
WARE CARL F (US)
BANKS THERESIA A (US)
International Classes:
C12N5/00; A61K39/00
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