Title:
LINCOMYCIN BIOSYNTHETIC INTERMEDIATES, METHOD FOR PREPARATION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/070849
Kind Code:
A1
Abstract:
Provided in the present invention are a class of Lincomycin biosynthetic intermediates and a preparation method and use thereof. Specifically provided are Lincomycin biosynthetic intermediates obtained from the genetic modification of a Lincomycin producing bacterium, and a method for the production thereof through fermentation and purification through separation.
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Inventors:
LIU WEN (CN)
WANG MIN (CN)
XU DONGXIAO (CN)
ZHAO QUNFEI (CN)
ZHANG QINGLIN (CN)
WANG MIN (CN)
XU DONGXIAO (CN)
ZHAO QUNFEI (CN)
ZHANG QINGLIN (CN)
Application Number:
PCT/CN2015/094047
Publication Date:
May 12, 2016
Filing Date:
November 06, 2015
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEM (CN)
HUZHOU CT OF BIO SYNTHETIC INNOVATION SHANGHAI INST OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN)
HUZHOU CT OF BIO SYNTHETIC INNOVATION SHANGHAI INST OF ORGANIC CHEMISTRY CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C07H15/207; A61K31/7034; A61K31/7056; A61P31/04; A61P31/10; C07D207/16; C07D233/84; C07H1/00; C07H5/10; C07H13/10; C07H17/02; C12N1/20
Domestic Patent References:
| WO2010127645A2 | 2010-11-11 |
Foreign References:
| CN102250991A | 2011-11-23 |
Other References:
ZHAO, QUNFEI.: "Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A", NATURE, vol. 518, no. 7537, 14 January 2015 (2015-01-14), LONDON, UNITED KINGDOM, XP055278300, ISSN: 0028-0836
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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