Title:
LINDERAPYRONE, AND ANALOGUE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/215522
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula (I) [the definition of each symbol in the formula is as described in the specification], or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient. According to the present invention, it is possible to provide a Wnt signaling pathway inhibitor which is useful for treating cancer, etc., and contains the compound or the pharmaceutically acceptable salt thereof as an active ingredient.
Inventors:
MATSUMOTO TAKAHIRO (JP)
ASHIHARA EISHI (JP)
WATANABE TETSUSHI (JP)
ASHIHARA EISHI (JP)
WATANABE TETSUSHI (JP)
Application Number:
PCT/JP2021/016391
Publication Date:
October 28, 2021
Filing Date:
April 23, 2021
Export Citation:
Assignee:
KYOTO PHARMACEUTICAL UNIV (JP)
International Classes:
A61P9/00; A61K31/366; A61K31/381; A61P19/02; A61P35/00; A61P35/02; A61P43/00; C07D493/08
Other References:
ICHINO KAZUHIKO, HITOSHI TANAKA, KAZUO ITO: "A new flavanone, neolindera-tone, from Lindera umbellata THUMB. Var. lancea MOMIYAMA", CHEM. PHARM. BULL., 1 January 1989 (1989-01-01), pages 1426 - 1427, XP055867887, Retrieved from the Internet [retrieved on 20211201]
KURODA MINPEI, SAKURAI KOICHIRO, MIMAKI YOSHIHIRO: "Chemical constituents of the stems and twigs of Lindera umbellata", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 65, no. 1, 1 January 2011 (2011-01-01), JP , pages 198 - 201, XP055867889, ISSN: 1340-3443, DOI: 10.1007/s11418-010-0454-1
MIMAKI YOSHIHIRO, A KAMEYAMA, Y SASHIDA, Y MIYATA, A FUJII: "A novel hexahydrodibenzofuran derivative with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells from Lindera umbellata bark", CHEM. PHARM. BULL., 1 January 1995 (1995-01-01), pages 893 - 895, XP055867894, Retrieved from the Internet [retrieved on 20211201], DOI: 10.1248/cpb.43.893
YOSHIDA MASAHIRO; SHIBATA MIKI; MUKAE SAAYA; KINOSHITA KOUKI; MATSUMOTO KENJI; HIROKANE TSUKASA: "Synthesis of pyrone-annulated 2-oxabicyclo[3.3.1]nonanes by palladium-catalyzed cyclization of 4-hydroxy-2-pyrones with allylic bisacetates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 60, no. 49, 11 October 2019 (2019-10-11), Amsterdam , NL , XP085913223, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2019.151262
KURODA MINPEI, SAKURAI KOICHIRO, MIMAKI YOSHIHIRO: "Chemical constituents of the stems and twigs of Lindera umbellata", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 65, no. 1, 1 January 2011 (2011-01-01), JP , pages 198 - 201, XP055867889, ISSN: 1340-3443, DOI: 10.1007/s11418-010-0454-1
MIMAKI YOSHIHIRO, A KAMEYAMA, Y SASHIDA, Y MIYATA, A FUJII: "A novel hexahydrodibenzofuran derivative with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells from Lindera umbellata bark", CHEM. PHARM. BULL., 1 January 1995 (1995-01-01), pages 893 - 895, XP055867894, Retrieved from the Internet
YOSHIDA MASAHIRO; SHIBATA MIKI; MUKAE SAAYA; KINOSHITA KOUKI; MATSUMOTO KENJI; HIROKANE TSUKASA: "Synthesis of pyrone-annulated 2-oxabicyclo[3.3.1]nonanes by palladium-catalyzed cyclization of 4-hydroxy-2-pyrones with allylic bisacetates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 60, no. 49, 11 October 2019 (2019-10-11), Amsterdam , NL , XP085913223, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2019.151262
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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