Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2023/280227
Kind Code:
A2
Abstract:
The present invention provides Polar units, Linker intermediates, Linkers, Drug-Linkers and Conjugates thereof

Inventors:
SHANG XIAO (US)
LIU HAIDONG (CN)
GAVRILYUK JULIA (US)
ZHAO BAITENG (US)
HAN TAE (US)
Application Number:
PCT/CN2022/104174
Publication Date:
January 12, 2023
Filing Date:
July 06, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
PROFOUNDBIO US CO (US)
International Classes:
A61K47/65; C07C211/00; C07H5/06; C07K5/02; C07K5/083; C07K5/09
Domestic Patent References:
WO2011136645A12011-11-03
WO2018031690A12018-02-15
WO2015095755A12015-06-25
WO2015123679A12015-08-20
WO2007008603A12007-01-18
WO2004010957A22004-02-05
WO2017096311A12017-06-08
WO2016040684A12016-03-17
WO2013173337A22013-11-21
WO2013012961A22013-01-24
WO2019213046A12019-11-07
WO1994011026A21994-05-26
WO2015104406A22015-07-16
WO2006029879A22006-03-23
WO2005100402A12005-10-27
WO2004056312A22004-07-08
WO2012130831A12012-10-04
WO1999051642A11999-10-14
WO2001029242A22001-04-26
WO1987002671A11987-05-07
WO1993008829A11993-05-13
WO2009089004A12009-07-16
WO2004106381A12004-12-09
WO2005061547A22005-07-07
WO2007042261A22007-04-19
WO2008119567A22008-10-09
WO2008024188A22008-02-28
WO2007024715A22007-03-01
WO1996021666A11996-07-18
WO2000008033A12000-02-17
WO2020156189A12020-08-06
WO2018170179A12018-09-20
WO2020056198A22020-03-19
WO2020056194A12020-03-19
WO2016142250A12016-09-15
WO2017046112A12017-03-23
WO2007024612A22007-03-01
WO2011022508A22011-02-24
WO2011022509A22011-02-24
WO2012045090A22012-04-05
WO2012097173A22012-07-19
WO2012097177A22012-07-19
WO2017079283A12017-05-11
WO2017216054A12017-12-21
WO2017190669A12017-11-09
WO2017202704A12017-11-30
WO2017202703A12017-11-30
WO2017071944A12017-05-04
WO2014056953A12014-04-17
WO2014076221A12014-05-22
WO2014128189A12014-08-28
WO2014023813A12014-02-13
WO2018198091A12018-11-01
WO2020059895A12020-03-26
WO2015077354A12015-05-28
WO2020227159A22020-11-12
WO2020075790A12020-04-16
WO2018200812A12018-11-01
WO2020074004A12020-04-16
Foreign References:
US5208020A1993-05-04
US20150297748A12015-10-22
US20080166363A12008-07-10
US20120328564A12012-12-27
US20200347075A12020-11-05
US6214345B12001-04-10
US9345785B22016-05-24
US5122368A1992-06-16
US5824805A1998-10-20
US5622929A1997-04-22
US4880935A1989-11-14
US20050238649A12005-10-27
US20220048951A12022-02-17
US20220016258A12022-01-20
US5500362A1996-03-19
US5821337A1998-10-13
US20190079077A12019-03-14
US20190048078A12019-02-14
US6737056B12004-05-18
US7332581B22008-02-19
US6194551B12001-02-27
US20060270045A12006-11-30
US20030167531A12003-09-04
US6080560A2000-06-27
US6512162B22003-01-28
US4946778A1990-08-07
US4704692A1987-11-03
US5731168A1998-03-24
US4676980A1987-06-30
US20060025576A12006-02-02
EP1691833A22006-08-23
US20210008099A12021-01-14
US20170121282A12017-05-04
US20130309192A12013-11-21
US20130157960A12013-06-20
US20010018422A12001-08-30
US4256746A1981-03-17
US4361650A1982-11-30
US4307016A1981-12-22
US4294757A1981-10-13
US4424219A1984-01-03
US4331598A1982-05-25
US4450254A1984-05-22
US4313946A1982-02-02
US4315929A1982-02-16
US4362663A1982-12-07
US4322348A1982-03-30
US4371533A1983-02-01
US20160229862A12016-08-11
US20160168164A12016-06-16
US20150299194A12015-10-22
US20110098248A12011-04-28
US20100143301A12010-06-10
US20090047249A12009-02-19
US20160008374A12016-01-14
US20160194350A12016-07-07
US20160289229A12016-10-06
US6043238A2000-03-28
US20180086755A12018-03-29
US20140045849A12014-02-13
US20140073642A12014-03-13
US20140350031A12014-11-27
US20080234251A12008-09-25
US20080306050A12008-12-11
US20100029585A12010-02-04
US20110092485A12011-04-21
US20110118235A12011-05-19
US20120082658A12012-04-05
US20120219615A12012-08-30
US20140066432A12014-03-06
US20140088085A12014-03-27
US20140275167A12014-09-18
US20130251673A12013-09-26
US20170131421A12017-05-11
US20210015942A12021-01-21
US20210015929A12021-01-21
US20200392131A12020-12-17
US20200216507A12020-07-09
US20200199247A12020-06-25
US20190175612A12019-06-13
Other References:
HAMBLETT ET AL., CLINICAL CANCER RES., vol. 10, 2004, pages 7063 - 70
JUNUTULA ET AL., CLINICAL CANCER RES., vol. 16, 2010, pages 4769
JAIN ET AL., PHARM. RES., vol. 32, 2015, pages 3526 - 3540
CHARI ET AL., CANCER RES., vol. 52, 1992, pages 127 - 131
DUBOWCHIKWALKER, PHARM. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
NEVILLE ET AL., BIOL. CHEM., vol. 264, 1989, pages 14653 - 14661
THORPE ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK ET AL.: "Immunoconjugates", 1987, OXFORD U. PRESS, article "Antibody Conjugates in Radioimagery and Therapy of"
JOHNSON ET AL., ANTICANCER RES, vol. 15, 1995, pages 1387 - 93
LAU ET AL., BIOORG-MED-CHEM, vol. 3, no. 10, 1995, pages 1305 - 1304
KANEKO, T. ET AL., BIOCONJUGATE CHEM, vol. 2, 1991, pages 133 - 41
HUSTON ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
JOHNSTON ET AL., SCIENCE, vol. 242, 1988, pages 1038 - 1041
HOLLINGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 64446448 - 6448
POLJAK, R. J ET AL., STRUCTURE, vol. 2, 1994, pages 1121 - 1123
HASLER ET AL., MOL. IMMUNOL., vol. 75, 2016, pages 28 - 37
COSSINS ET AL., PROT EXPRESS PURIF, vol. 51, 2006, pages 253 - 259
LI ET AL., IMMUNOL. LETT., vol. 188, 2017, pages 89 - 95
MUYLDERMANS ET AL., TIBS, vol. 26, 2001, pages 230 - 235
YAU ET AL., J IMMUNOL METHODS, vol. 281, 2003, pages 161 - 75
MAASS ET AL., J IMMUNOL METHODS, vol. 324, 2007, pages 13 - 25
BRINKMANNKONTERMANN, MABS, vol. 9, no. 2, 2017, pages 182 - 212
WANG ET AL., ANTIBODIES, vol. 8, 2019, pages 28
DONG ET AL., MABS, vol. 3, 2011, pages 273 - 88
NATSUME ET AL., J. BIOCHEM., vol. 140, no. 3, 2006, pages 359 - 368
CHEAL ET AL., MOL. CANCER THER., vol. 13, no. 7, 2014, pages 1803 - 1812
TEELING ET AL., J. IMMUNOL., vol. 177, 2006, pages 362 - 371
VAZQUEZ-LOMBARDI ET AL., DRUG DISCOVERY TODAY, vol. 20, no. 10, 2015, pages 1271 - 1283
SIMEONCHEN, PROTEIN CELL, vol. 9, no. 1, 2018, pages 3 - 14
BINZ ET AL., NATURE BIOTECHNOL., vol. 23, 2005, pages 1257 - 1268
ALI, J. BIOL. CHEM., vol. 274, 1999, pages 24066 - 24073
HEY ET AL., TRENDS BIOTECHNOL., vol. 23, no. 10, 2005, pages 514 - 522
KIPRIYANOV, S. M. ET AL., HUMAN ANTIBODIES AND HYBRIDOMAS, vol. 6, 1995, pages 93 - 101
KIPRIYANOV, S. M. ET AL., MOL. IMMUNOL., vol. 31, 1994, pages 10471058
RAVETCHKINET, ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 492
HELLSTROM, I. ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 83, 1986, pages 7059 - 7063
HELLSTROM, I ET AL., PROC. NAT'L ACAD., vol. 82, 1985, pages 1499 - 1502
BRUGGEMANN, M. ET AL., J. EXP. MED., vol. 166, 1987, pages 1351 - 1361
CLYNES ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 95, 1998, pages 652 - 656
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
CRAGG, M. S. ET AL., BLOOD, vol. 101, 2003, pages 1045 - 1052
CRAGG, M. S.M. J. GLENNIE, BLOOD, vol. 103, 2004, pages 2738 - 2743
SHIELDS ET AL., J. BIOL. CHEM., vol. 9, no. 2, 2001, pages 6591 - 6604
IDUSOGIE ET AL., J. IMMUNOL., vol. 164, 2000, pages 4178 - 4184
GORMAN ET AL., PNAS, vol. 79, 1982, pages 6777
WEIDLE ET AL., GENE, vol. 51, 1987, pages 21
MILLER ET AL., BIO/TECHNOL, vol. 7, 1989, pages 698
GROSSCHEDL ET AL., CELL, vol. 41, 1985, pages 885
HITZMAN ET AL., 11TH INTL. CONF. YEAST, GENETICS & MOLEC. BIOL., 1982
BRENNAN ET AL., SCIENCE, vol. 229, 1985, pages 81
SITARAMAN ET AL., METHODS MOL. BIOL., vol. 498, 2009, pages 229 - 44
SPIRIN, TRENDS BIOTECHNOL., vol. 22, 2004, pages 538 - 45
ENDO ET AL., BIOTECHNOL. ADV., vol. 21, 2003, pages 695 - 713
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
WARD ET AL., NATURE, vol. 334, 1989, pages 544 - 54
HOUSTON, J. S., METHODS IN ENZYMOL., vol. 203, 1991, pages 46 - 96
RAAGWHITLOW, FASEB, vol. 9, 1995, pages 73 - 80
BIRDWALKER, TIBTECH, vol. 9, 1991, pages 132 - 137
SOKOLOWSKA-WEDZINA ET AL., MOL. CANCER RES., vol. 15, no. 8, 2017, pages 1040 - 1050
MILSTEINCUELLO, NATURE, vol. 305, 1983, pages 537
TRAUNECKER ET AL., EMBO J., vol. 10, 1991, pages 3655
CARTER, J IMMUNOL METHODS, vol. 248, 2001, pages 7 - 15
KOSTELNY ET AL., J. IMMUNOL., vol. 148, no. 5, 1992, pages 1547 - 1553
GRUBER ET AL., J. IMMUNOL., vol. 152, 1994, pages 5368
TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60
WU ET AL., NAT BIOTECHNOL, vol. 25, 2007, pages 1290 - 97
CHELIUS ET AL., MABS, vol. 2, no. 3, 2010, pages 309 - 319
"Immunol. Meth.", vol. 1,2, 1979, ACAD. PRESS
PETTIT ET AL., J. AM. CHEM. SOC., vol. 109, 1987, pages 6883 - 6885
PETTIT ET AL., ANTICANCER DRUG DES., vol. 13, 1998, pages 243 - 277
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
Download PDF: