Title:
LIPID COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/246581
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a lipid composition which enables excellent nucleic acid delivery. According to the present invention, a lipid composition is provided, which contains a lipid represented by formula (1) or a salt thereof, a nonionic lipid, a lipid having a nonionic hydrophilic polymer structure and a nucleic acid and contains or does not contain a zwitterionic lipid, wherein the requirement represented by the formula: 40 < (A)-(B) ≦ 90 is satisfied, in which (A) represents the molar ratio, in terms of percentage, of the lipid represented by formula (1) or the salt thereof to all of the lipids constituting the lipid composition and (B) represents the molar ratio, in terms of percentage, of the zwitterionic lipid to all of the lipids constituting the lipid composition. In the formula, X represents -NR1- or -O-; R1 represents a hydrogen atom, a hydrocarbon group or the like; R2 and R3 independently represent a hydrogen atom, a hydrocarbon group or the like; R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently represent a hydrogen atom or an alkyl group; residues of at least one pair selected from R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom; and a, b, c and d independently represent an integer of 0 to 3, wherein a+b is 1 or more and c+d is 1 or more.
Inventors:
ENDO TAISUKE (JP)
KANEUMI SHUN (JP)
NORO MASAKI (JP)
TANABE SHINTARO (JP)
YAMAMOTO MASAHIKO (JP)
KANEUMI SHUN (JP)
NORO MASAKI (JP)
TANABE SHINTARO (JP)
YAMAMOTO MASAHIKO (JP)
Application Number:
PCT/JP2020/022279
Publication Date:
December 10, 2020
Filing Date:
June 05, 2020
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
A61K48/00; A61K9/10; A61K31/7088; A61K31/713; A61K47/14; A61K47/18; A61K47/24; A61K47/28; A61K47/34; A61P7/02
Domestic Patent References:
| WO2015095340A1 | 2015-06-25 | |||
| WO2015095346A1 | 2015-06-25 | |||
| WO2019235635A1 | 2019-12-12 | |||
| WO2010054401A1 | 2010-05-14 | |||
| WO2010054405A1 | 2010-05-14 | |||
| WO2009127060A1 | 2009-10-22 | |||
| WO2010144740A1 | 2010-12-16 | |||
| WO2016081029A1 | 2016-05-26 | |||
| WO2010054401A1 | 2010-05-14 | |||
| WO2015005253A1 | 2015-01-15 |
Foreign References:
| JP2012530059A | 2012-11-29 | |||
| JP5288254B2 | 2013-09-11 | |||
| JP2014529328A | 2014-11-06 |
Other References:
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY & SONS, INC, pages: 696 - 926
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, 2016, pages 134 - 145
NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 172 - 176
See also references of EP 3981435A4
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, 2016, pages 134 - 145
NATURE BIOTECHNOLOGY, vol. 28, 2010, pages 172 - 176
See also references of EP 3981435A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
Download PDF: