Title:
LIPID COMPOUND, LIPID CARRIER BASED ON LIPID COMPOUND, NUCLEIC ACID LIPID NANOPARTICLE COMPOSITION AND PHARMACEUTICAL FORMULATION
Document Type and Number:
WIPO Patent Application WO/2023/179497
Kind Code:
A1
Abstract:
The present invention belongs to the field of gene drug delivery, and particularly relates to a lipid compound, a lipid carrier based on the lipid compound, a nucleic acid lipid nanoparticle composition and a pharmaceutical formulation. The compound having the structure shown in formula (I) can independently prepare a lipid carrier, or jointly prepare a lipid carrier with other lipid compounds. The lipid carrier shows pH responsiveness, has high encapsulation efficiency on nucleic acid drugs, and is beneficial to improving the in vivo delivery efficiency of nucleic acid drugs. Moreover, the lipid carrier can also deliver a nucleic acid drug to an organ needing enrichment, and has a good application prospect.
Inventors:
HUANG KE (CN)
GE BINXI (CN)
GAO YINJIA (CN)
ZHANG NAN (CN)
DONG ZHAOFANG (CN)
SUN ZHENHUA (CN)
GE BINXI (CN)
GAO YINJIA (CN)
ZHANG NAN (CN)
DONG ZHAOFANG (CN)
SUN ZHENHUA (CN)
Application Number:
PCT/CN2023/082278
Publication Date:
September 28, 2023
Filing Date:
March 17, 2023
Export Citation:
Assignee:
SUZHOU CUREMED BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07C229/16; A61K9/127; A61K9/51; A61K47/18; A61K48/00; A61P31/14; C07C219/06; C07C291/00; C07C323/52; C07C327/06
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Attorney, Agent or Firm:
LINDA LIU & PARTNERS et al. (CN)
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