Title:
LIPID COMPOUND, COMPOSITION CONTAINING SAME, AND USE
Document Type and Number:
WIPO Patent Application WO/2023/134325
Kind Code:
A1
Abstract:
A lipid compound, a composition containing same, and a use, the lipid compound being prepared by means of a ring-opening reaction of organic amine and glycidyl ester, and the structure not containing free amino groups. The lipid compound can be ionized into a cationic compound under acidic conditions and is then bound with a negatively charged active pharmaceutical ingredient by means of electrostatic interaction, thereby assembling into a drug-loaded lipid nanoparticle for delivery of the pharmaceutical active ingredient. The lipid compound has a simple structure, a simple reaction path and a high yield. The constructed drug-loaded lipid nanoparticle can be used to prepare nucleic acid drugs, gene vaccines, polypeptide or protein drugs and small molecule drugs, and has broad application prospects.
Inventors:
ZHANG YUAN (CN)
GU FEI (CN)
GU FEI (CN)
Application Number:
PCT/CN2022/136397
Publication Date:
July 20, 2023
Filing Date:
December 02, 2022
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
C07D295/13; A61K31/221; A61K31/40; A61K31/495; A61P3/00; A61P9/00; A61P25/00; A61P31/18; A61P35/00; A61P37/02; C07C219/06
Domestic Patent References:
| WO2017100744A1 | 2017-06-15 | |||
| WO2014028487A1 | 2014-02-20 |
Foreign References:
| US3931430A | 1976-01-06 | |||
| CN102245559A | 2011-11-16 | |||
| CN114507195A | 2022-05-17 |
Other References:
KIM TAE-SEONG, HA JEONG-WOOK, KIM DONG-IL, RANG MOON-JEONG, AHN HO-JEONG: "Preparation of Quaternary Ammonium Salts Containing Ester Groups from Epichlorohydrin", NIHON YUKAGAKU KAISHI [= JOURNAL OF JAPAN OIL CHEMISTS' SOCIETY], NIHON YUKAGAKKAI, TOKYO, JP, vol. 49, no. 7, 1 January 2000 (2000-01-01), JP , pages 701 - 706,733, XP093079519, ISSN: 1341-8327, DOI: 10.5650/jos1996.49.701
Attorney, Agent or Firm:
YOGO PATENT & TRADEMARK AGENCY LIMITED COMPANY (CN)
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