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Title:
LIPID COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012272
Kind Code:
A1
Abstract:
Provided in the present application are a new lipid compound, a lipid nanoparticle containing same and the use thereof in the targeted delivery of a drug. Specifically, provided in the present application are a compound of general formula I, or a pharmaceutically acceptable salt, a prodrug or a stereoisomer thereof. Further provided in the present application is a lipid nanoparticle, which contains a compound of general formula I or a pharmaceutically acceptable salt, a prodrug or a stereoisomer thereof. Furthermore, the lipid nanoparticle may also contain a cationic lipid. In addition, the lipid nanoparticle may also contain an auxiliary lipid. The composition containing the compound, or the pharmaceutically acceptable salt, the prodrug or the stereoisomer thereof or the lipid nanoparticle can achieve the targeted organ delivery function of a therapeutic agent/prophylactic agent.

Inventors:
ZHANG LEI (CN)
CHEN JIANXIN (CN)
YAN LU (CN)
PENG WEI (CN)
MA QIAOQIAO (CN)
Application Number:
PCT/CN2023/104925
Publication Date:
January 18, 2024
Filing Date:
June 30, 2023
Export Citation:
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Assignee:
THEMEDIUM THERAPEUTICS CO LTD (CN)
International Classes:
A61K47/16; A61K9/127; A61K31/7105; A61K47/06; A61K47/12; C07C69/40
Domestic Patent References:
WO2022060871A12022-03-24
WO2022140404A12022-06-30
WO2017075531A12017-05-04
Foreign References:
CN114127044A2022-03-01
CN113264842A2021-08-17
US4548955A1985-10-22
CN111386105A2020-07-07
CN107708739A2018-02-16
CN112930198A2021-06-08
CN112424214A2021-02-26
Other References:
STEPHAN GRABBE ET AL., TRANSLATING NANOPARTICULATE-PERSONALIZED CANCER VACCINES INTO CLINICAL APPLICATIONS: CASE STUDY WITH RNA-LIPOPLEXES FOR THE TREATMENT OF MELANOMA, 2016
CHENG QIANG ET AL., SELECTIVE ORGAN TARGETING (SORT) NANOPARTICLES FOR TISSUE-SPECIFIC MRNA DELIVERY AND CRISPR-CAS GENE EDITING, 2020
Attorney, Agent or Firm:
BEIJING YUEHE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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