Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2022/247755
Kind Code:
A1
Abstract:
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol andpolymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Inventors:
YING BO (CN)
WANG XIULIAN (CN)
Application Number:
PCT/CN2022/094227
Publication Date:
December 01, 2022
Filing Date:
May 20, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SUZHOU ABOGEN BIOSCIENCES CO LTD (CN)
International Classes:
C07C217/08; A61K9/127; A61K9/51; A61K31/7105; A61K47/18; C07C211/58; C07C217/28; C07C219/06; C07C219/14; C07C229/12; C07C229/14; C07C229/16; C07C229/24; C07C229/30; C07C233/36; C07C235/06; C07C237/06; C07C271/12; C07C271/20; C07D207/12; C07D211/58; C07D295/125; C07F9/22; C07F9/24
Domestic Patent References:
WO1997013743A11997-04-17
WO2022152109A22022-07-21
WO2012067378A22012-05-24
WO2015199952A12015-12-30
WO2016176330A12016-11-03
WO2015011633A12015-01-29
WO2017112865A12017-06-29
WO2008127688A12008-10-23
WO2008016473A22008-02-07
WO2011015347A12011-02-10
WO2007025008A22007-03-01
WO2001055369A12001-08-02
WO2009075886A12009-06-18
WO2012009644A22012-01-19
WO1999024595A11999-05-20
WO2001055371A12001-08-02
WO2013103659A12013-07-11
WO2012019780A12012-02-16
WO2015002667A12015-01-08
WO2013120497A12013-08-22
WO2013120629A12013-08-22
WO2013120500A12013-08-22
WO2013120627A12013-08-22
WO2013120498A12013-08-22
WO2013120626A12013-08-22
WO2013120499A12013-08-22
WO2013120628A12013-08-22
WO2002098443A22002-12-12
WO2003051401A22003-06-26
WO2008052770A22008-05-08
WO2009127230A12009-10-22
WO2006122828A22006-11-23
WO2008083949A22008-07-17
WO2010088927A12010-08-12
WO2010037539A12010-04-08
WO2004004743A12004-01-15
WO2005016376A12005-02-24
WO2006024518A12006-03-09
WO2007095976A22007-08-30
WO2008014979A22008-02-07
WO2008077592A12008-07-03
WO2009030481A12009-03-12
WO2009095226A22009-08-06
WO2011069586A12011-06-16
WO2011026641A12011-03-10
WO2011144358A12011-11-24
WO2012013326A12012-02-02
WO2012089338A12012-07-05
WO2012113513A12012-08-30
WO2012116811A12012-09-07
WO2012116810A12012-09-07
WO2013113502A12013-08-08
WO2013113501A12013-08-08
WO2013113736A12013-08-08
WO2013143698A12013-10-03
WO2013143699A12013-10-03
WO2013143700A22013-10-03
WO2013174409A12013-11-28
WO2014127917A12014-08-28
WO2015024669A12015-02-26
WO2015024668A22015-02-26
WO2015024667A12015-02-26
WO2015024665A12015-02-26
WO2015024666A12015-02-26
WO2015024664A12015-02-26
WO2015101415A12015-07-09
WO2015101414A22015-07-09
WO2015062738A12015-05-07
WO2015101416A12015-07-09
Foreign References:
US5965434A1999-10-12
CN2021122704W2021-10-08
CN2022071251W2022-01-11
US8519110B22013-08-27
US7468275B22008-12-23
US20070048776A12007-03-01
US20110124100A12011-05-26
US6310197B12001-10-30
US6849405B22005-02-01
US7456273B22008-11-25
US7183395B22007-02-27
US20090226470A12009-09-10
US20130177581A12013-07-11
US20090093049A12009-04-09
EP2610341A12013-07-03
EP2610340A12013-07-03
Other References:
BENNETT M J ET AL: "A Flexible Approach to Synthetic Lipid Ammonium Salts for Polynucleotide Transfection", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 36, no. 13, 27 March 1995 (1995-03-27), pages 2207 - 2210, XP004028439, ISSN: 0040-4039, DOI: 10.1016/0040-4039(95)00276-I
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OSANAI, SHUICHI ET AL: "Preparation of optically active double-chained diammonium cationic amphiphiles and their surface and colloidal properties", XP055955505, retrieved from STN Database accession no. 1992:447611
SCHURZ H H ET AL: "ANALYTICAL MEASUREMENTS OF PRODUCTS OF ANILINE AND TRIGLYCERIDES IN OIL SAMPLES ASSOCIATED WITH THE TOXIC OIL SYNDROME", ARCHIVES OF TOXICOLOGY SUPPLEMENTS, SPRINGER VERLAG, DE, vol. 19, 1 January 1997 (1997-01-01), pages 53 - 64, XP009085859, ISSN: 0171-9750
BUNDGARD, H.: "Design of Prodrugs", 1985, ELSEVIER
HIGUCHI, T. ET AL.: "Bioreversible Carriers in Drug Design", vol. 14, 1987, PERGAMON PRESS, article "A.C.S. Symposium Series"
WELLENSIEK ET AL.: "Genome-wide profiling of human cap-independent translation-enhancing elements", NATURE METHODS, vol. 10, no. 8, August 2013 (2013-08-01), pages 747 - 750, XP055658496, DOI: 10.1038/nmeth.2522
CHAPPELL ET AL., PNAS, vol. 101, no. 26, 29 June 2004 (2004-06-29), pages 9590 - 9594
PANEK ET AL., NUCLEIC ACIDS RESEARCH, vol. 41, 1 September 2013 (2013-09-01), pages 7625 - 7634
ANTIBODY ENGINEERING, 1995
KUBY, IMMUNOLOGY, 1997
HARLOWLANE, ANTIBODIES: A LABORATORY MANUAL, 1989
MOL. BIOLOGY AND BIOTECHNOLOGY: A COMPREHENSIVE DESK REFERENCE, 1995
HUSTON ET AL., CELL BIOPHYSICS, vol. 22, 1993, pages 189 - 224
PLIICKTHUNSKERRA, METH. ENZYMOL., vol. 178, 1989, pages 497 - 515
DAY, ADVANCED IMMUNOCHEMISTRY, 1990
SABNIS ET AL.: "A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates", MOLECULAR THERAPY, vol. 26, no. 6, 2018, XP055644778, DOI: 10.1016/j.ymthe.2018.03.010
KORE ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4570 - 4574
CHAPPELL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 9590 - 9594
ZHOU ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 6273 - 6278
KEDDE ET AL.: "A Pumilio-induced RNA structure switch in p27-3'UTR controls miR-221 and miR-222 accessibility", NAT CELL BIOL., vol. 12, no. 10, October 2010 (2010-10-01), pages 1014 - 20
"Remington's The Science and Practice of Pharmacy", 2006, LIPPINCOTT, WILLIAMS & WILKINS
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: BATTERY CONTROL CIRCUIT, BATTERY AND RELATED ELECTRONIC DEVICE

Next Patent: CHIMERIC ANTIGEN RECEPTOR TARGETING GPRC5D, AND USE THEREOF