Title:
LIPID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1986/004894
Kind Code:
A1
Abstract:
Lipid derivatives represented by formula (I), wherein R1 represents alkyl or alkylcarbamoyl, R2 represents hydrogen, optionally substituted hydroxy, optionally substituted amino or cyclic amino, R3 represents a bond or optionally substituted alkylene, R4 represents hydrogen, alkyl or aralkyl, X and Y each represents O, S or optionally substituted imino, provided that, when Y is imino, it may form a ring together with an imino group represented by X or with R4, and Z represents optionally substituted imino or nitrogen-containing heterocyclic ring, and salts thereof have a PAF-inhibiting effect, and are useful as agents for prophylaxis and treatment of various circulatory organ diseases, allergic diseases, and as antineoplastic agents.
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Inventors:
NOMURA HIROAKI (JP)
NISHIKAWA KOHEI (JP)
TSUSHIMA SUSUMU (JP)
NISHIKAWA KOHEI (JP)
TSUSHIMA SUSUMU (JP)
Application Number:
PCT/JP1985/000062
Publication Date:
August 28, 1986
Filing Date:
February 15, 1985
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
International Classes:
C07C275/50; C07C275/60; C07D207/09; C07D209/48; C07D211/56; C07D213/40; C07D213/75; C07D233/72; C07D239/54; C07D277/22; C07D277/28; C07D295/088; C07D295/13; C07D295/205; C07D295/215; C07D401/06; C07D401/12; C07D405/12; C07D417/06; C07D417/12; C07D521/00; (IPC1-7): C07C93/16; C07C125/065; C07C125/073; C07C125/077; C07C154/00; C07C155/02; C07D211/56; C07D213/40; C07D213/75; C07D233/72; C07D239/55; C07D277/28; C07D295/20; C07D401/06; C07D417/06
Foreign References:
| JPS5931738A | 1984-02-20 | |||
| JPS5988447A | 1984-05-22 | |||
| JPS59110663A | 1984-06-26 |
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