Title:
LIPID MEMBRANE STRUCTURE
Document Type and Number:
WIPO Patent Application WO2010110471
Kind Code:
A1
Abstract:
Provided are a lipid membrane structure that is for delivering substances into the cytoplasm of a target cell and has INF7 surface modifications; and a lipid membrane structure that is for delivering substances into the nucleus of a target cell, encapsulates the substance to be delivered on the interior thereof, and has a surface modified with three or more oligosaccharide compounds.
Inventors:
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
EL-SAYED AYMAN
MASUDA TOMOYA
IJIRO KUNIHARU
NIIKURA KENICHI
NISHIO TAKASHI
AKITA HIDETAKA
EL-SAYED AYMAN
MASUDA TOMOYA
IJIRO KUNIHARU
NIIKURA KENICHI
NISHIO TAKASHI
Application Number:
PCT/JP2010/055493
Publication Date:
September 30, 2010
Filing Date:
March 23, 2010
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
EL-SAYED AYMAN
MASUDA TOMOYA
IJIRO KUNIHARU
NIIKURA KENICHI
NISHIO TAKASHI
HARASHIMA HIDEYOSHI
AKITA HIDETAKA
EL-SAYED AYMAN
MASUDA TOMOYA
IJIRO KUNIHARU
NIIKURA KENICHI
NISHIO TAKASHI
International Classes:
C12N15/09; A61K9/127; A61K31/7088; A61K47/26; A61K47/34
Domestic Patent References:
| WO2005032593A1 | 2005-04-14 | |||
| WO2007102481A1 | 2007-09-13 | |||
| WO2006101201A1 | 2006-09-28 |
Foreign References:
| JP2004010481A | 2004-01-15 | |||
| JPH02149512A | 1990-06-08 |
Other References:
KOGURE, K. ET AL.: "Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method", J. CONTROL. RELEASE, vol. 98, 2004, pages 317 - 323, XP004521720, DOI: doi:10.1016/j.jconrel.2004.04.024
ESBJORNER, E. K. ET AL.: "Membrane binding of pH-sensitive influenza fusion peptides. positioning, configuration, and induced leakage in a lipid vesicle model", BIOCHEMISTRY, vol. 46, no. 47, 2007, pages 13490 - 13504
EL-SAYED, A. ET AL.: "Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape", J. CONTROL. RELEASE, vol. 138, no. 2, 1 September 2009 (2009-09-01), pages 160 - 167, XP026394868
VAN ROSSENBERG, S. M. ET AL.: "Targeted lysosome disruptive elements for improvement of parenchymal liver cell-specific gene delivery", J. BIOL. CHEM., vol. 277, no. 48, 29 November 2002 (2002-11-29), pages 45803 - 45810
ESBJORNER, E. K. ET AL.: "Membrane binding of pH-sensitive influenza fusion peptides. positioning, configuration, and induced leakage in a lipid vesicle model", BIOCHEMISTRY, vol. 46, no. 47, 2007, pages 13490 - 13504
EL-SAYED, A. ET AL.: "Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape", J. CONTROL. RELEASE, vol. 138, no. 2, 1 September 2009 (2009-09-01), pages 160 - 167, XP026394868
VAN ROSSENBERG, S. M. ET AL.: "Targeted lysosome disruptive elements for improvement of parenchymal liver cell-specific gene delivery", J. BIOL. CHEM., vol. 277, no. 48, 29 November 2002 (2002-11-29), pages 45803 - 45810
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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