Title:
LIPID MICROBUBBLE LYOPHILIZED POWDER COMPOSITION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/051474
Kind Code:
A1
Abstract:
Provided are a lipid microbubble lyophilized powder composition and a preparation method therefor. The composition comprises 1 part by weight of distearoylphosphatidylcholine, 1 part by weight of sodium 1,2-palmitoylphosphatidylglycerol, 100-240 parts by weight of polyethylene glycol 4000, and 0.1-0.3 parts by weight of palmitic acid. The lyophilized powder composition and a physiologically acceptable gas form a sealed vial. The lyophilized powder composition is used for ultrasonic contrast after reconstitution. By adjusting the proportion of each component of the lipid microbubble lyophilized powder composition and process parameters, the lipid microbubble lyophilized powder composition is made to have the advantages of a narrow particle size distribution of reconstituted microbubbles, high microbubble stability, being less likely to crack, good pressure resistance, etc. During ultrasonic contrast, the composition can achieve stronger image acoustic signals and stay longer at the target part.
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Inventors:
FENG PUCHUN (CN)
LI XIANG (CN)
LIU SUYUN (CN)
LI XIANG (CN)
LIU SUYUN (CN)
Application Number:
PCT/CN2023/113783
Publication Date:
March 14, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
BEIJING QI HUI BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K49/22; A61J1/00
Foreign References:
| CN115970010A | 2023-04-18 | |||
| US10335502B1 | 2019-07-02 | |||
| CN113825529A | 2021-12-21 | |||
| US20010024638A1 | 2001-09-27 | |||
| CN114177317A | 2022-03-15 | |||
| CN113440627A | 2021-09-28 | |||
| CN113811335A | 2021-12-17 | |||
| CN112165959A | 2021-01-01 |
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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