Title:
LIPID NANOPARTICLE LYOPHILIZED COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/060440
Kind Code:
A1
Abstract:
Provided is a lyophilized composition in which an arbitrary nucleic acid can be highly efficiently and easily encapsulated. This lipid nanoparticle lyophilized composition is free from nucleic acids and contains an ionic lipid, sterol, a PEG-lipid, an acidic buffer solution component having a buffering action at a pH of 1-6, and a cryoprotectant. The weight ratio of the cryoprotectant and all the lipids is 10:1 to 1000:1.
More Like This:
| JP4840792 | Treatment of PML for JC virus agno |
| WO2003072114 | VASCULAR THERAPEUTICS |
| JP2000511428 | [Title of Invention] Antisense Nucleic Acid and Hammerhead Ribozyme |
Inventors:
TANGE KOTA (JP)
NAKAI YUTA (JP)
TAMAGAWA SHINYA (JP)
TANEICHI SAKURA (JP)
AKITA HIDETAKA (JP)
TANAKA HIROKI (JP)
SHIRANE DAIKI (JP)
HAGIWARA SHINYA (JP)
NAKAI YUTA (JP)
TAMAGAWA SHINYA (JP)
TANEICHI SAKURA (JP)
AKITA HIDETAKA (JP)
TANAKA HIROKI (JP)
SHIRANE DAIKI (JP)
HAGIWARA SHINYA (JP)
Application Number:
PCT/JP2020/036196
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
NOF CORP (JP)
UNIV CHIBA NAT UNIV CORP (JP)
UNIV CHIBA NAT UNIV CORP (JP)
International Classes:
A61K48/00; A61K9/19; A61K31/7088; A61K47/10; A61K47/24; A61K47/26; A61K47/28; A61K47/44; A61K47/69; C12N15/09
Domestic Patent References:
| WO2016121942A1 | 2016-08-04 | |||
| WO2013073480A1 | 2013-05-23 | |||
| WO2019188867A1 | 2019-10-03 | |||
| WO2016121942A1 | 2016-08-04 |
Foreign References:
| JP2011172519A | 2011-09-08 | |||
| JP2005525992A | 2005-09-02 | |||
| JPH10501822A | 1998-02-17 | |||
| JP2019525901A | 2019-09-12 | |||
| US20140335157A1 | 2014-11-13 | |||
| JP2019176253A | 2019-10-10 |
Other References:
SHIRANE, D. ET AL.: "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA", BIOL. PHARM. BULL., vol. 41, 2018, pages 1291 - 1294, XP055813159
GENE THERAPY, vol. 6, 1999, pages 271 - 281
BIOL. PHARM. BULL., vol. 41, 2018, pages 1291 - 1294
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
BIOMATERIALS, vol. 32, 2011, pages 6342
GENE THERAPY, vol. 6, 1999, pages 271 - 281
BIOL. PHARM. BULL., vol. 41, 2018, pages 1291 - 1294
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
BIOMATERIALS, vol. 32, 2011, pages 6342
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
Download PDF: