Title:
LIPID NANOPARTICLES FOR DELIVERING NUCLEIC ACID TO SPLENIC TISSUE, AND METHOD FOR DELIVERING NUCLEIC ACID TO SPLENIC TISSUE USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/190176
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: lipid nanoparticles for delivering a nucleic acid to splenic tissue, which can improve the efficiency of delivery of a nucleic acid to splenic tissue cells; and a method for delivering a nucleic acid to splenic tissue using the lipid nanoparticles. Provided are: lipid nanoparticles that are used for the delivery of a nucleic acid to splenic tissue, each of the lipid nanoparticles comprising (A) an ionic lipid represented by formula (1), (B) an anionic lipid or a compound represented by formula (2), (C) cholesterol, and (D) dimyristoyl glycerol PEG represented by the formula CH2(OR6)-CH(OR7)-CH2(OR8) (In the formulae, the definitions for the symbols are as described in the description.); and a method for delivering a nucleic acid to splenic tissue using the lipid nanoparticles.
Inventors:
NAKAI YUTA (JP)
TANGE KOTA (JP)
SAKURAI YU (JP)
AKITA HIDETAKA (JP)
TANAKA HIROKI (JP)
HORI MIZUHO (JP)
GOMI MASAKI (JP)
TANGE KOTA (JP)
SAKURAI YU (JP)
AKITA HIDETAKA (JP)
TANAKA HIROKI (JP)
HORI MIZUHO (JP)
GOMI MASAKI (JP)
Application Number:
PCT/JP2023/011850
Publication Date:
October 05, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
NOF CORP (JP)
UNIV TOHOKU (JP)
UNIV CHIBA NAT UNIV CORP (JP)
UNIV TOHOKU (JP)
UNIV CHIBA NAT UNIV CORP (JP)
International Classes:
A61K47/20; A61K9/10; A61K9/14; A61K31/7088; A61K47/14; A61K47/24; A61K47/28; A61K48/00; A61P37/04
Domestic Patent References:
| WO2021060440A1 | 2021-04-01 |
Other References:
LOPRESTI SAMUEL T.; ARRAL MARIAH L.; CHAUDHARY NAMIT; WHITEHEAD KATHRYN A.: "The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 345, 26 March 2022 (2022-03-26), AMSTERDAM, NL , pages 819 - 831, XP087063332, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2022.03.046
WENJIN GUO, ROBERT J LEE: "Efficient Gene Delivery Using Anionic Liposome-Complexed Polyplexes (LPDII)", BIOSCIENCE REPORTS, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NEW YORK, 1 October 2000 (2000-10-01), New York , pages 419 - 432, XP055198601, Retrieved from the Internet DOI: 10.1023/A:1010338219401
WENJIN GUO, ROBERT J LEE: "Efficient Gene Delivery Using Anionic Liposome-Complexed Polyplexes (LPDII)", BIOSCIENCE REPORTS, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NEW YORK, 1 October 2000 (2000-10-01), New York , pages 419 - 432, XP055198601, Retrieved from the Internet
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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